ATOH1:Protein atonal homolog 1

Gene Name
Protein atonal homolog 1
Protein ID
Chromosome ID
HPP Status
Protein Name
Protein atonal homolog 1

atonal homolog 1 (Drosophila)

protein atonal homolog 1

Class A basic helix-loop-helix protein 14


Helix-loop-helix protein hATH-1


class A basic helix-loop-helix protein 14



helix-loop-helix protein hATH-1



[Reference: ]
Chromosomal Position
4q22.2 | Start:93828753 End:93828753

Entrez Gene Summary for ATOH1
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ATOH1
Function: Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)

[Reference: ]
External IDs
Hgnc ID: 797 EntrezGene ID: 474 Ensembl ID: ENSG00000172238
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
11889557Maps to 10q21-22. Candidate gene for optic nerve aplasia and related syndromes.2010-01-21
12209986Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma2010-01-21
16382053Hath1 may regulate the expression of MUC2, a mucin secreted by goblet cells, and Hath1 may also be a novel factor normally repressed as a consequence of activation of the Wnt signaling pathway [review]2010-01-21
16647036Hath1 is one of the transcriptional regulators for MUC6 and MUC5AC in gastric cancer cells.2010-01-21
16831200Based on these results, we hypothesize that Cdx2 is involved in activating Math1 expression in intestinal epithelial cells.2010-01-21
17000673HATH1 is an important factor in the up-regulation of MUC2 expression that occurs in mucinous cancers and signet ring carcinomas.2010-01-21
17241872GSK3beta-dependent protein degradation was switched between Hath1 and beta-catenin by Wnt signaling, leading to the dramatic alteration of cell status between proliferation and differentiation in colon cancer2010-01-21
17397818In the chimeric environment, genotypically wild-type cells that possess Math1 have the competence to differentiate into hair cells by providing appropriate environmental interactions.2010-01-21
17549667Patients with ATOH1-expressing adenocarcinomas might have a worse prognosis.2010-01-21
17826772ATOH1 activates hairy and enhancer of split 6 transcription through binding to three clustered E boxes of its promoter2010-01-21
18275842Hath1 protein degradation may be required for maintaining the undifferentiated state of colon cancers, and that GSK3 inhibitors have potential for use in cancer therapy.2010-01-21
19243219Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation.2010-01-21
19741118Adult Atoh1-conditional knock-out mice are behaviorally deaf, have diminished auditory brainstem responses and disrupted auditory nuclei morphology.2010-01-21
19924642we investigated by immunohistochemistry the expression of Hath1 in 63 neuroendocrine tumors2010-02-01
20621629Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells.2010-09-27
21125297Longitudinal cell formation in the small intestine was regulated by the colocalization of Hath1 and Klf4 that converted Paneth cell differentiation into goblet cell differentiation.2011-07-16
22147253Math1/Atoh1 ectopic expression significantly reduced cell proliferation and altered cell morphology in Barrett esophagus2012-05-12
22370966involved in differentiation of neurons, secretory cells in the gut, and mechanoreceptors including auditory hair cells [review]2012-09-08
22573682In vivo conversion of pillar cells and Deiters' cells into immature auditory hair cells by Atoh1 is age dependent and resembles normal auditory hair cell development.2012-07-07
22573692Atoh1 activates cell proliferation within the normally postmitotic cochlear epithelium.2012-07-07
22786753H. pylori up-regulates Hath1 expression through inducing the release of IL-8 in MKN28 cells.2013-03-09
22985730Transfection of hATOH1 in combination with hTCF3 or hGATA3 induced 2-3X more Pou4f3/GFP cells, and similarly enhanced Pou4f3/GFP and myosin VIIa double-positive cells, when compared to hATOH1 alone2013-03-02
23030416Nuclear expression of Atoh1 was inversely correlated with the differentiation and primary tumor stage of lung cancers and also the downregulation of the Wnt pathway.2013-03-16
23333391the Atoh1 protein regulates malignant potential rather than the differentiation phenotype of mucinous colon cancer (MC), suggesting the mechanism by which MC and signet ring cell carcinoma are more malignant than non-mucinous adenocarcinoma.2013-09-21
23464457Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected.2014-10-11
23724999The transcription factor Atoh1, which is both necessary and sufficient for hair cell development.2013-10-26
24141260cotransfection of Pax2 and Math1 strongly stimulates in situ hair cell regeneration in neomycin-damaged cochlear explants.2014-07-12
24904172Atoh1 transfection drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons.2014-10-04
25015561ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype.2016-03-19
25400808Data suggest that Atoh1 high expression correlates with a good prognosis and it may serve as a favorable prognostic factor for GIST.2015-07-25
25412697Chicken Atoh1 might have intrinsic functional differences to mammalian Atoh1.2015-10-03
25648190In this review, expression of the Atoh1 gene in supporting cells, results in their transformation into immature hair cells.2015-08-22
25950549ATOH1 can induce the differentiation of gastric cancer stem cells.2016-05-07
25957791Testosterone-bovine serum albumin and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation.2016-03-05
26017781Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer2015-10-31
26487780Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea2016-02-20


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceATOH1_HUMANFER3L_MOUSE3544652.1712.992201722171161610.00000000559
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ATOH1_HUMANIPR011598GO:0046983DomainMyc-type, basic helix-loop-helix (bHLH) domainMolecular Functionprotein dimerization activity
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM