UGT2B11:UDP-glucuronosyltransferase 2B11

Gene Name
UDP-glucuronosyltransferase 2B11
Protein ID
O75310
Chromosome ID
4
HPP Status
2
Protein Name
UDP-glucuronosyltransferase 2B11
Synonyms

UDP glucuronosyltransferase 2 family, polypeptide B11

UDP glycosyltransferase 2 family protein

UDPGT 2B11

UDP glycosyltransferase 2 family, polypeptide B11

UDP-glucuronosyltransferase 2B11

EC 2.4.1.17


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=UGT2B11 ]
Chromosomal Position
4q13.2 | Start:69004618 End:69004618
Sequence
O75310.fasta
Description

UniProtKB Summary for UGT2B11
Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=UGT2B11 ]
External IDs
Hgnc ID: 12545 EntrezGene ID: 10720 Ensembl ID: ENSG00000213759
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=UGT2B11 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19343046Observational study of gene-disease association. (HuGE Navigator)2009-04-29
19898482Observational study of gene-disease association. (HuGE Navigator)2009-12-02
20214802Observational study of gene-disease association. (HuGE Navigator)2010-04-07
21679149significant expression of UGT2B11 was detected in the liver, breast and kidney, and was clearly different from the distribution of UGT2B282011-12-31
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceUDB11_HUMANUDB18_MACFA52952986.39100720152915290972
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
UDB11_HUMANIPR002213GO:0008152FamilyUDP-glucuronosyl/UDP-glucosyltransferaseBiological Processmetabolic process
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00040KEGG PATHWAYPentose and glucuronate interconversions
hsa00053KEGG PATHWAYAscorbate and aldarate metabolism
hsa00140KEGG PATHWAYSteroid hormone biosynthesis
hsa00500KEGG PATHWAYStarch and sucrose metabolism
hsa00514KEGG PATHWAYOther types of O-glycan biosynthesis
hsa00830KEGG PATHWAYRetinol metabolism
hsa00860KEGG PATHWAYPorphyrin and chlorophyll metabolism
hsa00980KEGG PATHWAYMetabolism of xenobiotics by cytochrome P450
hsa00982KEGG PATHWAYDrug metabolism - cytochrome P450
hsa00983KEGG PATHWAYDrug metabolism - other enzymes
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O75310_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


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Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
LDFNTMSSTDLLNALKMaxquant132.8401295888524-1
Evidence File
/mnt/mpp/ms_data/O75310_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB