RNF212:Probable E3 SUMO-protein ligase RNF212

Gene Name
Probable E3 SUMO-protein ligase RNF212
Protein ID
Chromosome ID
HPP Status
Protein Name
Probable E3 SUMO-protein ligase RNF212

ring finger protein 212


RING finger protein 212


probable E3 SUMO-protein ligase RNF212

hypothetical protein LOC285498

EC 6.3.2.-

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RNF212 ]
Chromosomal Position
4p16.3 | Start:1056250 End:1056250

Entrez Gene Summary for RNF212
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Oct 2010)

UniProtKB Summary for RNF212
Function: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RNF212 ]
External IDs
Hgnc ID: 27729 EntrezGene ID: 285498 Ensembl ID: ENSG00000178222
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RNF212 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
15340062This paper describes a partial transcript of the human RNF212 gene.2010-10-08
18239089Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2009-08-12
18239089genome search identified sequence variants in the 4p16.3 region correlated with recombination rate in males & females; variants are located in the RNF212 gene, a putative ortholog of ZHP-3 gene essential for recombination & chiasma formation in C elegans2010-01-21


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceRN212_HUMANRN212_MOUSE29719375.6564.98452119211923E-83304
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RN212_HUMANIPR001841GO:0005515DomainZinc finger, RING-typeMolecular Functionprotein binding
RN212_HUMANIPR001841GO:0008270DomainZinc finger, RING-typeMolecular Functionzinc ion binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Evidence File
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB