ST8SIA2:Alpha-2,8-sialyltransferase 8B

Gene Name
Alpha-2,8-sialyltransferase 8B
Protein ID
Q92186
Chromosome ID
15
HPP Status
2
Protein Name
Alpha-2,8-sialyltransferase 8B
Synonyms

sialyltransferase St8Sia II

ST8SIA-II

SIAT8B

ST8SiaII

Sialyltransferase St8Sia II

STX

Sialyltransferase X

sialyltransferase X

SIAT8-B

sialyltransferase 8 (alpha-2, 8-sialytransferase) B

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

sialyltransferase 8B

Sialyltransferase 8B

HsT19690

sialytransferase St8Sia II

alpha-2,8-sialyltransferase 8B

alpha-2,8-sialyltransferase 8B 1

EC 2.4.99.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ST8SIA2 ]
Chromosomal Position
15q26.1 | Start:92393828 End:92393828
Sequence
Q92186.fasta
Description

Entrez Gene Summary for ST8SIA2
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ST8SIA2
Function: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ST8SIA2 ]
External IDs
Hgnc ID: 10870 EntrezGene ID: 8128 Ensembl ID: ENSG00000140557
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ST8SIA2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12138100SIAT8B has a role in neural development and sialic acid synthesis on NCAM2010-01-21
15710344The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported.2010-01-21
16229822Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16229822SIAT8B gene is involved in schizophrenia in the Japanese.2010-01-21
17126533Observational study of gene-disease association. (HuGE Navigator)2008-03-13
19336400Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM.2010-01-21
20386566This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population.2011-08-20
20663923Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2010-09-15
21464126STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity2011-09-03
21555518ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.2011-09-14
22281821NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas.2012-05-12
22693595that variation the ST8SIA2 gene is associated with increased risk to mental illness2012-10-27
23643386Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass.2013-07-06
23671285translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid2013-09-14
24070986Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia.2015-08-08
24651862the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder2014-12-20
26418860Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I).2016-06-04
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SIA8B_HUMANIPR001675GO:0006486FamilyGlycosyl transferase, family 29Biological Processprotein glycosylation
SIA8B_HUMANIPR001675GO:0008373FamilyGlycosyl transferase, family 29Molecular Functionsialyltransferase activity
SIA8B_HUMANIPR012163GO:0006486FamilySialyltransferaseBiological Processprotein glycosylation
SIA8B_HUMANIPR012163GO:0008373FamilySialyltransferaseMolecular Functionsialyltransferase activity
SIA8B_HUMANIPR012163GO:0030173FamilySialyltransferaseCellular Componentintegral to Golgi membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q92186_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-1 of 1 item.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
DVGLKTDLVTMNPSVIQR0.0346941142517785,Mascot:expectation;23.91,Mascot:score;94.72,Mascot:PTM site assignment confidence;PXD003271_59988_88_Q92186_DVGLKTDLVTMNPSVIQRPXD003271;MR231.mgf;index=3291
Evidence File
/mnt/mpp/ms_data/Q92186_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q92186_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB