ST8SIA2:Alpha-2,8-sialyltransferase 8B

Gene Name
Alpha-2,8-sialyltransferase 8B
Protein ID
Chromosome ID
HPP Status
Protein Name
Alpha-2,8-sialyltransferase 8B

sialyltransferase St8Sia II




Sialyltransferase St8Sia II


Sialyltransferase X

sialyltransferase X


sialyltransferase 8 (alpha-2, 8-sialytransferase) B

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

sialyltransferase 8B

Sialyltransferase 8B


sialytransferase St8Sia II

alpha-2,8-sialyltransferase 8B

alpha-2,8-sialyltransferase 8B 1

EC 2.4.99.-

[Reference: ]
Chromosomal Position
15q26.1 | Start:92393828 End:92393828

Entrez Gene Summary for ST8SIA2
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ST8SIA2
Function: May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression

[Reference: ]
External IDs
Hgnc ID: 10870 EntrezGene ID: 8128 Ensembl ID: ENSG00000140557
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
12138100SIAT8B has a role in neural development and sialic acid synthesis on NCAM2010-01-21
15710344The upregulation of ST8SIA4 and the donwregulation of ST8SIA2 by valproic acid in HUVEC and tumor cell lines are reported.2010-01-21
16229822Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16229822SIAT8B gene is involved in schizophrenia in the Japanese.2010-01-21
17126533Observational study of gene-disease association. (HuGE Navigator)2008-03-13
19336400Amino acid substitutions in conserved sequences are critical for the protein-specific polysialylation of NCAM.2010-01-21
20386566This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population.2011-08-20
20663923Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2010-09-15
21464126STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity2011-09-03
21555518ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.2011-09-14
22281821NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas.2012-05-12
22693595that variation the ST8SIA2 gene is associated with increased risk to mental illness2012-10-27
23643386Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass.2013-07-06
23671285translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid2013-09-14
24070986Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia.2015-08-08
24651862the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder2014-12-20
26418860Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I).2016-06-04


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SIA8B_HUMANIPR001675GO:0006486FamilyGlycosyl transferase, family 29Biological Processprotein glycosylation
SIA8B_HUMANIPR001675GO:0008373FamilyGlycosyl transferase, family 29Molecular Functionsialyltransferase activity
SIA8B_HUMANIPR012163GO:0006486FamilySialyltransferaseBiological Processprotein glycosylation
SIA8B_HUMANIPR012163GO:0008373FamilySialyltransferaseMolecular Functionsialyltransferase activity
SIA8B_HUMANIPR012163GO:0030173FamilySialyltransferaseCellular Componentintegral to Golgi membrane
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM

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Peptide SequenceScoresPride IDSpectrum IDAnnotation
DVGLKTDLVTMNPSVIQR0.0346941142517785,Mascot:expectation;23.91,Mascot:score;94.72,Mascot:PTM site assignment confidence;PXD003271_59988_88_Q92186_DVGLKTDLVTMNPSVIQRPXD003271;MR231.mgf;index=3291
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB