Gene Name
Protein ID
Chromosome ID
HPP Status
Protein Name


Small solute channel 1


aquaporin 9

small solute channel 1





[Reference: ]
Chromosomal Position
15q21.3 | Start:58138169 End:58138169

Entrez Gene Summary for AQP9
The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. (provided by RefSeq, Jul 2008)

UniProtKB Summary for AQP9
Function: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol

[Reference: ]
External IDs
Hgnc ID: 643 EntrezGene ID: 366 Ensembl ID: ENSG00000103569
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
15336539AQP9 can modulate drug sensitivity in cancer.2010-01-21
15592307The APQ9 mRNA expression in fetal membranes suggest that APQ9 may be an important water channel in intramembranous amniotic fluid water regulation.2010-01-21
16480766results provide new evidences that suggest the involvement of AQP9 and UT-A in the urea excretion mechanism across human term placenta from mother to fetus in physiological conditions2010-01-21
17346701We propose that increased water influx through AQP9 is critically involved in the formation of membrane protrusions, and that AQP9-induced actin polymerization is augmented by activation of Cdc42 and PKC(zeta).2010-01-21
17525633The expression of AQP9 in glioblastoma was studied.2010-01-21
17545093Data show that AQP-1, 3, 8, 9 mRNA expression was detected in both amnion and chorion and can be associated with intramembranous transport and volume regulation of amniotic fluid.2010-08-23
18197497Up-regulated expression of AQP3 in ascending colon and down-regulated expression of AQP9 in descending colon are presented in patients with functional constipation as compared to patients without functional constipation.2010-03-15
18401671decreased hepatic AQP9 expression observed in obese T2DM subjects suggests a potential role in glycerol release from adipose tissue2010-01-21
18652774Results indicate that aquaporin-9 may play an important role in the malignant progression of brain astrocytic tumours.2010-01-21
18762715hAQP9 functions as a facilitative carrier for glycerol.2010-01-21
19100828The present study strongly suggests that membrane transporters responsible for arsenic uptake, such as AQP9, may play a critical role in development of arsenic resistance in human lung cancer cells.2010-01-21
19481256CFTR expression decreases in preeclampsia and may thus be implicated in the regulation of AQP9 activity2010-01-21
19615702we found a greater expression found in visceral fat, and between subcutaneous adipose aquaporin 7 and hepatic AQP9 gene expression within the context of human morbid obesity2010-01-21
19629726The examination was performed whether aquaporin (AQP) 9 is expressed in normal skeletal muscle at mRNA and protein levels.2010-06-14
19772916TXA(2) receptor mediates water influx through aquaporins in astrocytoma cells via TXA(2) receptor-mediated activation of G alpha(12/13), Rho A, Rho kinase and Na(+)/H(+)-exchanger.2010-01-21
19802720The results suggest that in addition to the initial uptake of trivalent inorganic As(III) inside cells, AQP9 plays a dual role in the detoxification of arsenic metabolites by facilitating efflux from cells.2010-05-03
19916714AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with term-not in labor membranes.2010-02-08
20220109Elevated serum levels of human chorionic gonadotrophin may be involved in increased aquaporin-9 protein expression in preeclamptic placenta explants via adenosine 3',5'-cyclic phosphate pathways.2011-08-06
20378617Hyperandrogenism in follicular fluid of women with polycystic ovary syndrome inhibited AQP-9 in granulosa cells through the PI3K pathway.2010-08-23
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20424473Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20587318insulin treatment inhibited the expression of AQP9 in normal liver cells2010-12-04
20732771When polyhydramnios occurs, expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta is an adaptive change.2011-02-26
20960106Genetic variation in the AQP9 gene is associated with femoral neck BMD in postmenopausal women, and may represent one of the susceptibility genes for phenotypes related to bone mass2011-02-05
20960106Observational study of gene-disease association. (HuGE Navigator)2010-12-05
21873454AQP9 plays an active role in neutrophil volume regulation and migration2011-12-31
21945491The expression levels of aquaporin 9 were approximately 2 times higher in the chorion cells than those in the amnion cells following arsenite administration.2012-01-14
22262958Aquaporin 9 is linked to the tumorigenesis of glioblastoma.2012-06-09
22319637Using transcriptional signatures of blood samples,identified S100A11 as a potential diagnostic marker of infective endocarditis, and AQP9 as a potential prognostic factor.2012-09-29
22425521There is a coordinated regulation of adipose AQP7 and hepatic AQP9 gene expression that is distorted in metabolic syndrome X. (Review)2013-02-16
22916037Multi-tissue gene expression studies reveal SERPINA1 and AQP9 variants as genes for atherosclerosis.2012-12-22
23238960Reduced expression of AQP9 in human fallopian tube may contribute to aspects of pathophysiology of tubal ectopic pregnancy.2013-11-16
23448163The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site.2013-11-02
23563754AQP9, rather than other biomarkers such as cell surface markers and chromosomal alterations, correlate closely with the sensitivity to arsenic trioxide in acute promyelocytic leukemia cell lines.2013-11-02
23573219The interplay of water fluxes through AQP9 and actin dynamics regulate the cellular protrusive and motile activity of cells.2013-10-26
23612070AQP9 expression is lower in patients with stage III colorectal cancer who do not respond to adjuvant chemotherapy2013-08-31
23866971Placental expression of the arsenic transporter AQP9 was positively associated with maternal urinary arsenic levels during pregnancy. AQP9 expression related to phospholipase ENPP2 expression which was positively associated with infant birth weight.2013-11-23
24086629AQP9 expressing glioma cells were negative for the brain tumor stem cell marker CD15.2014-07-19
24418844AQP9 downregulation together with the subsequent reduction in hepatic glycerol permeability in insulin-resistant states emerges as a compensatory mechanism whereby the liver counteracts further triacylglycerol accumulation2015-04-25
24463099REVIEW: the current knowledge on the role of the glycerol channels AQP7 and AQP9 in controlling glycerol metabolism in adipose tissue and liver2014-11-08
24643204The genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.2014-12-20
25105540Oleic acid-induced hepatic steatosis in HepG2 cells is associated with the coordinated regulation of aquaporin 3 and aquaporin 9 via activation of p38 signaling2015-12-19
25604497we suggest that AQP9 is involved in viral tropism and pathogenesis of Herpes simplex encephalitis2016-01-02
26313002the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells.2016-05-14


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

Showing 1-20 of 366 items.


Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Showing 1-2 of 2 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB