BMP5:Bone morphogenetic protein 5

Gene Name
Bone morphogenetic protein 5
Protein ID
P22003
Chromosome ID
6
HPP Status
2
Protein Name
Bone morphogenetic protein 5
Synonyms

bone morphogenenic protein-5

bone morphogenetic protein 5

BMP-5


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP5 ]
Chromosomal Position
6p12.1 | Start:55753645 End:55753645
Sequence
P22003.fasta
Description

Entrez Gene Summary for BMP5
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. (provided by RefSeq, Jul 2008)

UniProtKB Summary for BMP5
Function: Induces cartilage and bone formation

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP5 ]
External IDs
Hgnc ID: 1072 EntrezGene ID: 653 Ensembl ID: ENSG00000112175
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP5 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11642720The expression signals of BMP-5 mRNA in malignant schwannoma were relatively lower than in benign lesions2010-01-21
15516325BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells.2010-01-21
15861517To analyze the expression of bone morphogenetic proteins (BMPs) in prostate and breast cancers with established metastasis in bone2010-01-21
16542506BMP5 is expressed in normal synovial tissue and was decreased in osteoarthritis and rheumatoid arthritis.2010-01-21
17220169The differential allelic expression (DAE) of BMP5 in human mesenchymal tissues obtained from 16 donors undergoing joint replacement for treatment of osteoarthritis, was examined.2010-01-21
17656261Approximately half of the prostate tumors displayed increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci, which may account for their abnormal gene expression patterns in neoplastic prostate tissue.2010-01-21
19584291Quantitative PCR analysis revealed down-regulation of BMP2 and BMP5 in tissue samples from adrenocortical carcinoma and adrenocortical tumor cell lines compared with normal adrenal glands.2010-01-21
19935299Observational study of gene-disease association. (HuGE Navigator)2010-01-20
20021689Observational study of gene-disease association. (HuGE Navigator)2010-01-20
20021689Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility2010-02-01
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20734064Observational study of gene-disease association. (HuGE Navigator)2010-12-05
21319131BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis.2012-01-14
21704030Taken together, BMP4 and BMP5 simultaneously inhibit the growth and promote migration and invasion of the same pancreatic cells and thus exhibit a biphasic role with both detrimental and beneficial functions in pancreatic cancer progression2011-10-22
22844442CASP3 rs4862396, BMP5 rs3734444 and IRS2 rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer2012-12-08
23186552Data indicate significant association between the bone morphogenetic protein 5 (BMP5) microsatellite and knee osteoarthritis (OA) in women, but not in men.2015-05-16
24384427BMP5 and BMP7, involved in cardiomyocyte differentiation defect2014-06-28
24551273BMP5, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP5 signaling may play a pivotal role in disease development.2014-10-18
25030405Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.2015-07-25
25994008findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC2016-04-02
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceBMP5_HUMANBMP7_MOUSE45444363.6697.58129615454174305E-158553
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
BMP5_HUMANIPR001111GO:0008083DomainTransforming growth factor-beta, N-terminalMolecular Functiongrowth factor activity
BMP5_HUMANIPR001111GO:0040007DomainTransforming growth factor-beta, N-terminalBiological Processgrowth
BMP5_HUMANIPR001839GO:0008083DomainTransforming growth factor-beta, C-terminalMolecular Functiongrowth factor activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04340KEGG PATHWAYHedgehog signaling pathway
hsa04350KEGG PATHWAY@@TGF-beta signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P22003_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/P22003_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P22003_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB