NKX3-2:Homeobox protein Nkx-3.2

Gene Name
Homeobox protein Nkx-3.2
Protein ID
Chromosome ID
HPP Status
Protein Name
Homeobox protein Nkx-3.2


Bagpipe homeobox protein homolog 1

bagpipe homeobox homolog 1 (Drosophila)

homeobox protein NK-3 homolog B

bagpipe homeobox protein homolog 1

Homeobox protein NK-3 homolog B



homeobox protein Nkx-3.2


NK3 homeobox 2

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX3-2 ]
Chromosomal Position
4p15.33 | Start:13540830 End:13540830

Entrez Gene Summary for NKX3-2
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. (provided by RefSeq, Jul 2008)

UniProtKB Summary for NKX3-2
Function: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX3-2 ]
External IDs
Hgnc ID: 951 EntrezGene ID: 579 Ensembl ID: ENSG00000109705
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX3-2 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
15024065Data show that Meox1 activates the Bapx1 promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 and/or Pax9.2010-01-21
20004766NKX3-2 plays an important role in endochondral ossification of both the axial and appendicular skeleton in humans2010-01-21
21606193Data show that IkappaB kinase beta (IKKbeta) can be activated in the nucleus by Nkx3.2 in the absence of exogenous IKK-activating signals, allowing constitutive nuclear degradation of IkappaB-alpha.2011-10-08
22507129Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation2012-06-09
26245691Our findings indicate that BAPX-1/NKX-3.2 is a molecular switch that is involved in controlling the hypertrophic phenotype of the postdevelopmental (OA) articular chondrocyte.2016-02-06


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceNKX32_HUMANNKX32_MOUSE33333385.29100490133313332E-95345
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NKX32_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
NKX32_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
NKX32_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

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Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB