GPR31:12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Gene Name
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
Protein ID
O00270
Chromosome ID
6
HPP Status
2
Protein Name
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
Synonyms

probable G-protein coupled receptor 31

hydroxyeicosatetraenoic (HETE) acid receptor 1

HETER

G-protein coupled receptor 31

"12-(S)-HETE acid receptor"

12-(S)-HETE receptor

bA517H2.2 (G protein-coupled receptor 31)

HETER1

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

12-(S)-HETE acid receptor

12-HETER

G protein-coupled receptor 31

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) receptor

"hydroxyeicosatetraenoic (HETE) acid receptor 1"


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR31 ]
Chromosomal Position
6q27 | Start:167156271 End:167156271
Sequence
O00270.fasta
Description

UniProtKB Summary for GPR31
Function: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR31 ]
External IDs
Hgnc ID: 4486 EntrezGene ID: 2853 Ensembl ID: ENSG00000120436
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR31 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
2171239212-HETER represents the first identified high affinity receptor for the 12-(S)-HETE hydroxyl fatty acids.2011-11-26
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O00270_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O00270_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O00270_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB