GSX2:GS homeobox 2

Gene Name
GS homeobox 2
Protein ID
Q9BZM3
Chromosome ID
4
HPP Status
2
Protein Name
GS homeobox 2
Synonyms

GSH2

GS homeobox 2

Homeobox protein GSH-2

homeobox protein GSH-2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GSX2 ]
Chromosomal Position
4q12 | Start:54099523 End:54099523
Sequence
Q9BZM3.fasta
Description

UniProtKB Summary for GSX2
Function: Probable transcription factor that binds to the DNA sequence 5'-CNAATTAG-3' (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GSX2 ]
External IDs
Hgnc ID: 24959 EntrezGene ID: 170825 Ensembl ID: ENSG00000180613
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GSX2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11861295ectopically expressed in myeloid leukemic cells with t(4;12)(q11-q12;p13), suggesting that expression of GSH2 was deregulated by the translocation, indicating a variant leukemogenic mechanism for translocations involving the 5' end of ETV62010-01-21
19709628Gsx2 specifies striatal projection neuron and olfactory bulb interneuron identity at distinct time points during neurogenesis in transgenic mice.2010-01-21
21368052Transgenic mice lacking microRNAs miR-9-2 and miR-9-3 exhibit multiple defects of telencephalic structures which may be brought about by dysregulation of Foxg1, Nr2e1, Gsh2, and Meis2 expression.2011-05-14
22242181Gsx2 negatively regulates neurogenesis from postnatal progenitor cells.2012-05-12
258167404q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.2015-12-05
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceGSX2_HUMANHXA3_MOUSE3046165.5720.072102032631932531E-1993
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
GSX2_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
GSX2_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
GSX2_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9BZM3_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9BZM3_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB