NDST3:Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Gene Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Protein ID
O95803
Chromosome ID
4
HPP Status
2
Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Synonyms

NDST-3

N-HSST 3

glucosaminyl N-deacetylase/N-sulfotransferase 3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

hNDST-3

HSST3

GlcNAc N-deacetylase/ N-sulfotransferase 3

N-heparan sulfate sulfotransferase 3

Glucosaminyl N-deacetylase/N-sulfotransferase 3

EC 2.8.2.8


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NDST3 ]
Chromosomal Position
4q26 | Start:118033618 End:118033618
Sequence
O95803.fasta
Description

Entrez Gene Summary for NDST3
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. (provided by RefSeq, Nov 2008)

UniProtKB Summary for NDST3
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NDST3 ]
External IDs
Hgnc ID: 7682 EntrezGene ID: 9348 Ensembl ID: ENSG00000164100
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NDST3 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20332099Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20549515Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2010-09-15
24253340A case-control study evaluating the entire genome for genes associated with the risk of schizophrenia and bipolar disorder demnstrated polymorphisms of NDST3 in case patients.2014-06-21
25139529study provides evidence that the minor allele of rs11098403, an SNP near NDST3, is significantly associated with a reduced risk of schizophrenia in a Han Chinese population, further confirming the data obtained from Caucasians2015-07-25
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceNDST3_HUMANNDST1_RAT87388070.57100.825141873488201300
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NDST3_HUMANIPR000863GO:0008146DomainSulfotransferase domainMolecular Functionsulfotransferase activity
NDST3_HUMANIPR021930GO:0015016FamilyHeparan sulphate-N-deacetylaseMolecular Function[heparan sulfate]-glucosamine N-sulfotransferase activity
NDST3_HUMANIPR021930GO:0016787FamilyHeparan sulphate-N-deacetylaseMolecular Functionhydrolase activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00534KEGG PATHWAYGlycosaminoglycan biosynthesis - heparan sulfate
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-6 of 6 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
VKTPENLSPSISKgreen-8.151ENSP00000296499Proteotypic
VKTPENLSPSISKgreen-8.151ENSP00000296499Proteotypic
VKTPENLSPSISKgreen-6.551ENSP00000296499Proteotypic
VKTPENLSPSISKgreen-6.551ENSP00000296499Proteotypic
VKTPENLSPSISKgreen-6.351ENSP00000296499Proteotypic
VKTPENLSPSISKgreen-6.351ENSP00000296499Proteotypic
Evidence File
/mnt/mpp/ms_data/O95803_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/O95803_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB