B3GALT4:Beta-1,3-galactosyltransferase 4

Gene Name
Beta-1,3-galactosyltransferase 4
Protein ID
O96024
Chromosome ID
6
HPP Status
1
Protein Name
Beta-1,3-galactosyltransferase 4
Synonyms

Gal-T2

beta-1,3-galactosyltransferase 4

ganglioside galactosyltransferase

beta-1,3-GalTase 4

gal-T2

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4

Beta3Gal-T4

GALT4

Beta3GalT4

Beta-1,3-GalTase 4

beta-3-galactosyltransferase 4

GalT4

b3Gal-T4

GALT2

BETA3GALT4

Ganglioside galactosyltransferase

UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase

EC 2.4.1.62


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=B3GALT4 ]
Chromosomal Position
6p21.32 | Start:33277132 End:33277132
Sequence
O96024.fasta
Description

Entrez Gene Summary for B3GALT4
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. (provided by RefSeq, Jul 2008)

UniProtKB Summary for B3GALT4
Function: Involved in GM1/GD1B/GA1 ganglioside biosynthesis

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=B3GALT4 ]
External IDs
Hgnc ID: 919 EntrezGene ID: 8705 Ensembl ID: ENSG00000235863
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=B3GALT4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19225246We found beta3Gal-T4 and T5 enzymatic activity in ovarian cancer tissues, indicating that these enzymes are expressed at least in ovarian cancer2010-01-21
19851445Observational study of gene-disease association. (HuGE Navigator)2010-01-20
20594196Data showed that GM1/GD1b/GA1 synthase transfectant cells had definite reduction in cell growth and invasion.2011-02-26
21519903Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function2011-11-05
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
B3GT4_HUMANIPR002659GO:0006486FamilyGlycosyl transferase, family 31Biological Processprotein glycosylation
B3GT4_HUMANIPR002659GO:0008378FamilyGlycosyl transferase, family 31Molecular Functiongalactosyltransferase activity
B3GT4_HUMANIPR002659GO:0016020FamilyGlycosyl transferase, family 31Cellular Componentmembrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00604KEGG PATHWAYGlycosphingolipid biosynthesis - ganglio series
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 20 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
TDDDVYVNVPELVSELVLRgreen-12.6601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-12.6601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-11.2601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-11.2601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-11.0601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-11.0601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-8.7601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-8.7601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-8.2601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-8.2601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-7.5601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-7.5601ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.7231ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.7231ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-6.4601ENSP00000372696Proteotypic
TDDDVYVNVPELVSELVLRgreen-6.4601ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.3231ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.3231ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.1231ENSP00000372696Proteotypic
APLLPLEDVFVGVSARgreen-6.1231ENSP00000372696Proteotypic
Evidence File
/mnt/mpp/ms_data/O96024_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-2 of 2 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
TDDDVYVNVPELVSELVLRMaxquant185.0207911954082297
EAEQEGGQVLHSEEVPLLYLGRMaxquant115.63012292847902995
Evidence File
/mnt/mpp/ms_data/O96024_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB