ASB5:Ankyrin repeat and SOCS box protein 5

Gene Name
Ankyrin repeat and SOCS box protein 5
Protein ID
Chromosome ID
HPP Status
Protein Name
Ankyrin repeat and SOCS box protein 5

ankyrin repeat and SOCS box containing 5


ankyrin repeat and SOCS box-containing 5

SOCS box protein ASB-5

ankyrin repeat and SOCS box protein 5

[Reference: ]
Chromosomal Position
4q34.2 | Start:176213673 End:176213673

Entrez Gene Summary for ASB5
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ASB5
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity)

[Reference: ]
External IDs
Hgnc ID: 17180 EntrezGene ID: 140458 Ensembl ID: ENSG00000164122
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ASB5_HUMANIPR001496GO:0035556DomainSOCS protein, C-terminalBiological Processintracellular signal transduction
ASB5_HUMANIPR002110GO:0005515RepeatAnkyrin repeatMolecular Functionprotein binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM

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Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB