ZAR1:Zygote arrest protein 1

Gene Name
Zygote arrest protein 1
Protein ID
Q86SH2
Chromosome ID
4
HPP Status
1
Protein Name
Zygote arrest protein 1
Synonyms

zygote arrest 1

Z3CXXC6

3CxxC-type 6"

Oocyte-specific maternal effect factor

oocyte-specific maternal effect factor

zinc finger, 3CxxC-type 6

"zinc finger

zygote arrest protein 1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZAR1 ]
Chromosomal Position
4p11 | Start:48490252 End:48490252
Sequence
Q86SH2.fasta
Description

Entrez Gene Summary for ZAR1
This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. (provided by RefSeq, Jul 2013)

UniProtKB Summary for ZAR1
Function: Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZAR1 ]
External IDs
Hgnc ID: 20436 EntrezGene ID: 326340 Ensembl ID: ENSG00000182223
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZAR1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12773403The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life.2010-01-21
16551357Zygote arrest 1 (ZAR1) could be implicated in regulation of meiosis and post meiotic differentiation of male and female germ cells through expression of shorter splicing variants. Central role of this gene in early reproductive processes.2010-01-21
20654783we identified a frequently aberrant methylated region within the Zygote arrest 1 (ZAR1) gene in melanoma and demonstrated a distinct methylation pattern between melanoma and nevus.The involvement of ZAR1 in the carcinogenesis of melanoma remains unclear.2010-11-27
21206179Findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis.2011-05-07
23583134Hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome.2013-11-16
24787227ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis2015-01-03
25227574A decreased methylation level at CpG sites of ZAR1 exon 1/intron 1. CpGi could serve as a biomarker for invasive bladder cancer.2016-03-05
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianZAR1_HUMANZAR1_RAT42436455.7785.85117763424403615.00E-88322
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-14 of 14 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
AALGDEVLDGYVFPACPPCSYRred-10.211ENSP00000329803Proteotypic
AALGDEVLDGYVFPACPPCSYRred-10.211ENSP00000329803Proteotypic
LTAFLEGPGPAAGEQRred-9.291ENSP00000329803Proteotypic
LTAFLEGPGPAAGEQRred-9.291ENSP00000329803Proteotypic
EAAVAGEGPSPRred-8.1321ENSP00000329803Proteotypic
EAAVAGEGPSPRred-8.1321ENSP00000329803Proteotypic
EAAVAGEGPSPRred-7.7321ENSP00000329803Proteotypic
EAAVAGEGPSPRred-7.7321ENSP00000329803Proteotypic
LQGPEEGEVWTKred-7.141ENSP00000329803Proteotypic
LQGPEEGEVWTKred-7.141ENSP00000329803Proteotypic
VEDITCQSCKred-6.791ENSP00000329803Proteotypic
VEDITCQSCKred-6.791ENSP00000329803Proteotypic
LTAFLEGPGPAAGEQRred-6.391ENSP00000329803Proteotypic
LTAFLEGPGPAAGEQRred-6.391ENSP00000329803Proteotypic
Evidence File
/mnt/mpp/ms_data/Q86SH2_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q86SH2_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB