HMX2:Homeobox protein HMX2

Gene Name
Homeobox protein HMX2
Protein ID
A2RU54
Chromosome ID
10
HPP Status
2
Protein Name
Homeobox protein HMX2
Synonyms

homeobox protein HMX2

H6L

Nkx5-2

H6 family homeobox 2

homeo box (H6 family) 2

Homeobox protein H6 family member 2

homeobox protein H6 family member 2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMX2 ]
Chromosomal Position
10q26.13 | Start:123148122 End:123148122
Sequence
A2RU54.fasta
Description

Entrez Gene Summary for HMX2
The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. (provided by RefSeq, Aug 2012)

UniProtKB Summary for HMX2
Function: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMX2 ]
External IDs
Hgnc ID: 5018 EntrezGene ID: 3167 Ensembl ID: ENSG00000188816
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HMX2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19253379propose that hemizygous deletions of HMX2 and HMX3 are responsible for inner ear malformations, vestibular dysfunction, and congenital sensorineural hearing loss2010-01-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceHMX2_HUMANHMX3_MOUSE27314660.2753.484631312642073521.00E-40162
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/A2RU54_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/A2RU54_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/A2RU54_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB