NBR2:Next to BRCA1 gene 2 protein

Gene Name
Next to BRCA1 gene 2 protein
Protein ID
Chromosome ID
HPP Status
Protein Name
Next to BRCA1 gene 2 protein

neighbor of BRCA1 gene 2

"non-protein coding RNA 192"

neighbor of BRCA1 gene 2 (non-protein coding)

Neighbor of BRCA1 gene 2 protein


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NBR2 ]
Chromosomal Position
17q21.31 | Start:43125610 End:43125610

Entrez Gene Summary for NBR2
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 bases upstream of the last splice site for the transcript suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. (provided by RefSeq, Jul 2008)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NBR2 ]
External IDs
Hgnc ID: 20691 EntrezGene ID: 10230 Ensembl ID: ENSG00000198496
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NBR2 ]
Reference Source


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
All Reviewed HumanNBR2_HUMANNBR2_HUMAN11211210010000111211124.00E-61228
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB