CXXC4:CXXC-type zinc finger protein 4

Gene Name
CXXC-type zinc finger protein 4
Protein ID
Q9H2H0
Chromosome ID
4
HPP Status
2
Protein Name
CXXC-type zinc finger protein 4
Synonyms

IDAX

CXXC-type zinc finger protein 4

inhibition of the Dvl and axin complex protein

Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)

CXXC finger protein 4

CXXC finger 4

"Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)"

Inhibition of the Dvl and axin complex protein


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CXXC4 ]
Chromosomal Position
4q24 | Start:104468312 End:104468312
Sequence
Q9H2H0.fasta
Description

UniProtKB Summary for CXXC4
Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CXXC4 ]
External IDs
Hgnc ID: 24593 EntrezGene ID: 80319 Ensembl ID: ENSG00000168772
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CXXC4 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceCXXC4_HUMANCXXC4_RAT19819810010000119811981E-93338
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CXXC4_HUMANIPR002857GO:0003677DomainZinc finger, CXXC-typeMolecular FunctionDNA binding
CXXC4_HUMANIPR002857GO:0008270DomainZinc finger, CXXC-typeMolecular Functionzinc ion binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04310KEGG PATHWAYWnt signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9H2H0_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9H2H0_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB