CSHL1:Chorionic somatomammotropin hormone-like 1

Gene Name
Chorionic somatomammotropin hormone-like 1
Protein ID
Q14406
Chromosome ID
17
HPP Status
2
Protein Name
Chorionic somatomammotropin hormone-like 1
Synonyms

chorionic somatomammotropin CS-5

hCS-L

"chorionic somatomammotropin CS-5"

Lactogen-like

CSL

CSHP1

CS-5

growth hormone cluster

Chorionic somatomammotropin-like

chorionic somatomammotropin hormone-like 1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CSHL1 ]
Chromosomal Position
17q23.3 | Start:63909597 End:63909597
Sequence
Q14406.fasta
Description

Entrez Gene Summary for CSHL1
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CSHL1
Function: May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CSHL1 ]
External IDs
Hgnc ID: 2442 EntrezGene ID: 1444 Ensembl ID: ENSG00000204414
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CSHL1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q14406_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q14406_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q14406_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB