SLC16A5:Monocarboxylate transporter 6

Gene Name
Monocarboxylate transporter 6
Protein ID
O15375
Chromosome ID
17
HPP Status
2
Protein Name
Monocarboxylate transporter 6
Synonyms

monocarboxylate transporter 5

MCT 5

monocarboxylate transporter 6

solute carrier family 16 (monocarboxylate transporter), member 5

MCT5

MCT 6

solute carrier family 16, member 5 (monocarboxylic acid transporter 6)

Solute carrier family 16 member 5

solute carrier family 16 (monocarboxylic acid transporters), member 5

MCT6

Monocarboxylate transporter 5


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC16A5 ]
Chromosomal Position
17q25.1 | Start:75087727 End:75087727
Sequence
O15375.fasta
Description

Entrez Gene Summary for SLC16A5
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2012)

UniProtKB Summary for SLC16A5
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC16A5 ]
External IDs
Hgnc ID: 10926 EntrezGene ID: 9121 Ensembl ID: ENSG00000170190
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC16A5 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
22911660We demonstrated that SLC16A5 and ZNF206 displayed altered methylation patterns in the neuroblastoma genome2013-03-09
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
MOT6_HUMANIPR004743GO:0015355FamilyMonocarboxylate transporterMolecular Functionsecondary active monocarboxylate transmembrane transporter activity
MOT6_HUMANIPR004743GO:0015711FamilyMonocarboxylate transporterBiological Processorganic anion transport
MOT6_HUMANIPR004743GO:0016021FamilyMonocarboxylate transporterCellular Componentintegral to membrane
MOT6_HUMANIPR011701GO:0016021FamilyMajor facilitator superfamilyCellular Componentintegral to membrane
MOT6_HUMANIPR011701GO:0055085FamilyMajor facilitator superfamilyBiological Processtransmembrane transport
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-6 of 6 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
QAVAADALERDLFLEAKgreen-8.2221ENSP00000330141Proteotypic
QAVAADALERDLFLEAKgreen-8.2221ENSP00000330141Proteotypic
QAVAADALERDLFLEAKgreen-8.1221ENSP00000330141Proteotypic
QAVAADALERDLFLEAKgreen-8.1221ENSP00000330141Proteotypic
QAVAADALERDLFLEAKgreen-6.5221ENSP00000330141Proteotypic
QAVAADALERDLFLEAKgreen-6.5221ENSP00000330141Proteotypic
Evidence File
/mnt/mpp/ms_data/O15375_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/O15375_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O15375_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O15375_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB