CCNG2:Cyclin-G2

Gene Name
Cyclin-G2
Protein ID
Q16589
Chromosome ID
4
HPP Status
2
Protein Name
Cyclin-G2
Synonyms

cyclin-G2

cyclin G2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNG2 ]
Chromosomal Position
4q21.1 | Start:77157151 End:77157151
Sequence
Q16589.fasta
Description

Entrez Gene Summary for CCNG2
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CCNG2
Function: May play a role in growth regulation and in negative regulation of cell cycle progession

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNG2 ]
External IDs
Hgnc ID: 1593 EntrezGene ID: 901 Ensembl ID: ENSG00000138764
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCNG2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11956189cyclin G2 also associates with various PP2A B' regulatory subunits, as previously shown for cyclin G12010-01-21
12452053ectopic expression of cyclin G2 inhibits cell proliferation2010-01-21
16364039Involved in progression and regulation of telomerase2010-01-21
16608856Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter2010-01-21
17123511Cyclin G2 may modulate the cell cycle and cellular division processes through modulation of PP2A and centrosomal associated activities.2010-01-21
18025271Cyclin G2 expression is modulated by HER2 signaling through multiple pathways including phosphoinositide 3-kinase, c-jun NH(2)-terminal kinase, and mTOR signaling.2010-01-21
18754885our results suggest that cotylenin A and rapamycin induce inhibition of cancer cell growth through the induction of cyclin G2.2010-01-21
18784254The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2.2010-01-21
19559447Cyclin G2 appears to be a negative cell-cycle regulator in gastric cancer, and its expression seems to be inversely related to gastric cancer progression.2010-01-21
19738611Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20677014Observational study of gene-disease association. (HuGE Navigator)2010-09-15
21532621These findings showed that Nodal signaling promotes cyclin G2 transcription by upregulating FoxO3a expression, inhibiting FoxO3a phosphorylation and enhancing its synergistic interaction with Smads.2011-11-12
21688120Expression of cyclin G1 and G2 is strongly associated with nasopharyngeal carcinoma cell differentiation.2012-06-30
22589537Our results suggest that CycG2 contributes to DNA damage-induced G(2)/M checkpoint by enforcing checkpoint inhibition of CycB1-Cdc2 complexes.2012-09-15
22596188These findings show that FOXA1, but not ER- alpha, is essential for AHR(aryl hydrocarbon receptor) -dependent regulation of CCNG2(cyclin G2 ), assigning a role for FOXA1 in AHR action.2012-11-24
24059861Regulation of cyclin G2 is a key mechanism whereby insulin, insulin analogues and IGF-I stimulate cell proliferation.2014-03-08
24248541CCNG2 expression decreased in gastric cancer and correlated significantly T stages, lymph node metastasis, clinical stage, histological grade, and poor overall survival2014-06-07
24272084CCNG2 may play important roles as a negative regulator to kidney cancer ACHN cell by promoting degradation of CDK2.2014-06-14
24289643Low CCNG2 expression is associated with thyroid cancer.2014-08-16
24293374CCNG2 expression decreased in prostate cancer and correlated significantly with lymph node metastasis, clinic stage, and Gleason score.2014-06-14
24297335CCNG2 may play important roles as a negative regulator to esophageal cancer cell by promoting degradation of CDK2.2014-06-14
24307622The level of CCNG2 was correlated with T stages, lymph node metastasis, clinic stage, and histological grade (P < 0.05) in colorectal carcinoma.2014-06-14
24339739Cyclin G2-involved invasion in vitro and in vivo.2014-08-30
24708911Data shows the human CCNG2 and CDK4 expression of visceral adipose tissue are inversely associated with glucose and insulin resistance.2015-05-30
25117811miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients2014-12-20
25122062Data (from studies using BeWo cells, a choriocarcinoma cell line, as model of placentation) suggest that miR-378a-5p (microRNA 378a) inhibits cell differentiation in syncytiotrophoblasts, in part, by down-regulating CCNG2 (cyclin G2) expression.2015-05-23
25309979miR-93-CCNG2 axis may be involved in Laryngeal squamous cell carcinoma proliferation and progression.2015-08-15
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 72 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-15.01941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-14.61941ENSP00000315743Proteotypic
EKGLSLIEATPENDNTLCPGLRgreen-14.61941ENSP00000315743Proteotypic
Evidence File
/mnt/mpp/ms_data/Q16589_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM