APOL4:Apolipoprotein L4

Gene Name
Apolipoprotein L4
Protein ID
Q9BPW4
Chromosome ID
22
HPP Status
2
Protein Name
Apolipoprotein L4
Synonyms

Apolipoprotein L-IV

apolipoprotein L4

APOLIV

apolipoprotein L-IV

APOL-IV

ApoL-IV

apolipoprotein L, 4


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=APOL4 ]
Chromosomal Position
22q12.3 | Start:36189124 End:36189124
Sequence
Q9BPW4.fasta
Description

Entrez Gene Summary for APOL4
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. (provided by RefSeq, Jul 2008)

UniProtKB Summary for APOL4
Function: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=APOL4 ]
External IDs
Hgnc ID: 14867 EntrezGene ID: 80832 Ensembl ID: ENSG00000100336
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=APOL4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11944986APOL4 has been found only in humans and African green monkeys2002-07-16
15949655Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18632255An association of APOL1, 2 and 4 with schizophrenia was establised.2010-01-21
18632255Observational study of gene-disease association. (HuGE Navigator)2008-07-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
All Reviewed HumanAPOL4_HUMANAPOL4_HUMAN35135110010000135113510643
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
APOL4_HUMANIPR008405GO:0005576FamilyApolipoprotein LCellular Componentextracellular region
APOL4_HUMANIPR008405GO:0006869FamilyApolipoprotein LBiological Processlipid transport
APOL4_HUMANIPR008405GO:0008289FamilyApolipoprotein LMolecular Functionlipid binding
APOL4_HUMANIPR008405GO:0042157FamilyApolipoprotein LBiological Processlipoprotein metabolic process
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9BPW4_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9BPW4_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9BPW4_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB