MYL5:Myosin light chain 5

Gene Name
Myosin light chain 5
Protein ID
Q02045
Chromosome ID
4
HPP Status
2
Protein Name
Myosin light chain 5
Synonyms

myosin regulatory light chain 5

Myosin regulatory light chain 5

Superfast myosin regulatory light chain 2

myosin, light chain 5, regulatory

MYLC2

superfast myosin regulatory light chain 2

MyLC-2

myosin, light polypeptide 5, regulatory

myLC-2

myosin light chain 5


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYL5 ]
Chromosomal Position
4p16.3 | Start:673580 End:673580
Sequence
Q02045.fasta
Description

Entrez Gene Summary for MYL5
This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. (provided by RefSeq, Jul 2008)

Tocris Summary for MYL5
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYL5 ]
External IDs
Hgnc ID: 7586 EntrezGene ID: 4636 Ensembl ID: ENSG00000215375
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYL5 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20201926Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2010-04-07
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-18 of 18 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
AQRASSNVFSNFEQTQIQEFKgreen-8.41341ENSP00000423053Proteotypic
LSGTDAEETILNAFKred-6.5171ENSP00000425162Proteotypic
LSGTDAEETILNAFKred-6.5171ENSP00000425162Proteotypic
Evidence File
/mnt/mpp/ms_data/Q02045_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q02045_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB