ALPK2:Alpha-protein kinase 2

Gene Name
Alpha-protein kinase 2
Protein ID
Q86TB3
Chromosome ID
18
HPP Status
2
Protein Name
Alpha-protein kinase 2
Synonyms

"heart alpha-kinase"

heart alpha-protein kinase

alpha-protein kinase 2

Heart alpha-protein kinase

heart alpha-kinase

alpha-kinase 2

HAK

EC 2.7.11.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ALPK2 ]
Chromosomal Position
18q21.31 | Start:58481247 End:58481247
Sequence
Q86TB3.fasta
Description

UniProtKB Summary for ALPK2
Function: Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ALPK2 ]
External IDs
Hgnc ID: 20565 EntrezGene ID: 115701 Ensembl ID: ENSG00000198796
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ALPK2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19690890Observational study of gene-disease association. (HuGE Navigator)2009-09-20
22641666ALPK2 is crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma.2012-08-11
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ALPK2_HUMANIPR004166GO:0004674DomainMHCK/EF2 kinaseMolecular Functionprotein serine/threonine kinase activity
ALPK2_HUMANIPR004166GO:0005524DomainMHCK/EF2 kinaseMolecular FunctionATP binding
ALPK2_HUMANIPR004166GO:0006468DomainMHCK/EF2 kinaseBiological Processprotein phosphorylation
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 94 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
VENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKgreen-15.051ENSP00000354991Proteotypic
ADFREPVAVSVASPEPTDTALTLENVCDEPRgreen-15.021ENSP00000354991Proteotypic
IPSGCSIGQIQESSDGSLGEAEQSKKgreen-15.011ENSP00000354991Proteotypic
VENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKgreen-15.051ENSP00000354991Proteotypic
ADFREPVAVSVASPEPTDTALTLENVCDEPRgreen-15.021ENSP00000354991Proteotypic
IPSGCSIGQIQESSDGSLGEAEQSKKgreen-15.011ENSP00000354991Proteotypic
VSVVAETAGEEDSQALSNVPSLSDILLEESKgreen-13.721ENSP00000354991Proteotypic
VSVVAETAGEEDSQALSNVPSLSDILLEESKgreen-13.721ENSP00000354991Proteotypic
APSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKgreen-13.451ENSP00000354991Proteotypic
LLSGESENSGMSQCWETAADKRgreen-13.431ENSP00000354991Proteotypic
APSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKgreen-13.451ENSP00000354991Proteotypic
LLSGESENSGMSQCWETAADKRgreen-13.431ENSP00000354991Proteotypic
VENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKgreen-12.651ENSP00000354991Proteotypic
VENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKgreen-12.651ENSP00000354991Proteotypic
SPGTLTAVTGSEEVKgreen-11.981ENSP00000354991Proteotypic
LAAQECYVQNTARgreen-11.981ENSP00000354991Proteotypic
SPGTLTAVTGSEEVKgreen-11.981ENSP00000354991Proteotypic
LAAQECYVQNTARgreen-11.981ENSP00000354991Proteotypic
SPGTLTAVTGSEEVKgreen-11.681ENSP00000354991Proteotypic
SPGTLTAVTGSEEVKgreen-11.681ENSP00000354991Proteotypic
Evidence File
/mnt/mpp/ms_data/Q86TB3_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-1 of 1 item.

MaxQB

Peptide SequenceSearch EngineBest ScoreBest Evidence IDBest Raw File IDBest Msms ScanAnnotation
EDFLHDSYFGGRMaxQuant117.25135742920101227_Velos1_TaGe_SA_GAMG518121
Evidence File
/mnt/mpp/ms_data/Q86TB3_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q86TB3_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-5 of 5 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
NLVPTAHSPASSREGAGQRMaxquant258.360249486389127
AGKPEPSETTPQGARMaxquant213.060559089017250
APSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKMaxquant174.4308855490912417
LTDVGIATLAKMaxquant119.45011716418372678
LEEKENIRMaxquant118.330248898534145
Evidence File
/mnt/mpp/ms_data/Q86TB3_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB