ADRA2C:Alpha-2C adrenergic receptor

Gene Name
Alpha-2C adrenergic receptor
Protein ID
P18825
Chromosome ID
4
HPP Status
2
Protein Name
Alpha-2C adrenergic receptor
Synonyms

alpha-2C adrenoceptor

ADRA2RL2

ALPHA2CAR

ADRARL2

adrenoceptor alpha 2C

Alpha-2C adrenoceptor

Alpha-2C adrenoreceptor

alpha-2C-adrenergic receptor

alpha-2 adrenergic receptor subtype C4

alpha2-AR-C4

adrenergic, alpha-2C-, receptor

alpha-2C adrenoreceptor

alpha-2C adrenergic receptor

Alpha-2CAR

alpha-2CAR

ADRA2L2

Alpha-2 adrenergic receptor subtype C4


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA2C ]
Chromosomal Position
4p16.3 | Start:3766348 End:3766348
Sequence
P18825.fasta
Description

Entrez Gene Summary for ADRA2C
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ADRA2C
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins

Tocris Summary for ADRA2C
Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. Adrenergic alpha2 receptors are divided into three subtypes: alpha2A, alpha2B and alpha2C, which are widely distributed in both the CNS and periphery. Alpha2-adrenoceptors play a role in the modulation of neurotransmission, smooth muscle contraction and thermoregulation. A fourth pharmacological subtype, alpha2D, has been identified in the rat which is thought to be a species ortholog of the human alpha2A subtype.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA2C ]
External IDs
Hgnc ID: 283 EntrezGene ID: 152 Ensembl ID: ENSG00000184160
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA2C ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11140838Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-03-13
11317218Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)2008-03-13
12210281Observational study of gene-disease association. (HuGE Navigator)2008-03-13
12374873Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-03-13
12946937Alpha2-ARs in vascular smooth muscle cells reflect differential activity of alpha2-AR gene promoters. Alpha2C-ARs can be induced via p38 MAPK-dependent pathway.2010-01-21
15345481Increased expression of alpha(2C)-adrenoceptors may contribute to enhanced cold-induced vasoconstriction and Raynaud's phenomenon.2010-01-21
15542284Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15592690ADRA2C had one haplotype block of 10 kb2010-01-21
15592690Observational study of genotype prevalence. (HuGE Navigator)2008-03-13
15683753Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-03-13
15719258Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15861038Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15861038alpha2CDel322-325 polymorphism is associated with increased sympathetic nervous and adrenomedullary hormonal activities, both during supine rest and during pharmacologically evoked catecholamine release2010-01-21
15920038Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-03-13
15946904Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16187973Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16299019Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16407897A genetic variant of the alpha 2C-adrenoceptor subtype--resulting from the deletion of four consecutive amino acids at codons 322-325--confers a change in brain function playing a role in the pathogenesis of major depressive disorder.2010-01-21
16407897Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16464220Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16569551Genetic variations of the alpha and beta adrenergic receptors (alpha 2C Del322-325 allele) were found to be significant predictors of vasospastic angina2010-01-21
16605244Thus, the alpha(2C)AR alters alpha(2A)AR signaling by forming oligomers, and these complexes, which appear to be preferred over the homodimers, should be considered a functional signaling unit in cells in which both subtypes are expressed.2010-01-21
16636200Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17075692Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17192578alpha(2)-ARs might contribute neurotrophic actions in vivo synergistically or in permutation with other neurotrophic factors2010-01-21
17223428Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17351367Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17351367The ADRA2C deletion polymorphism had no effect on markers of resting sympathetic activity and cardiovascular measures, and did not account for ethnic differences in blood pressure.2010-01-21
17383306Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17496726Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-03-13
17644575An estrogen-dependent increase in expression of cold-sensitive alpha(2C)-ARs may contribute to the increased activity of cold-induced vasoconstriction under estrogen-replete conditions2010-01-21
17655760Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17971028Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18071056Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-03-13
18075481Polymorphisms are not associated with Toureett's syndrome in this study.2010-01-21
18308161Observational study of gene-disease association. (HuGE Navigator)2008-04-03
18320080Homozygosity for the alpha 2C Del322-325 polymorphism is not associated with heart failure in black South Africans2010-01-21
18320080Observational study of gene-disease association. (HuGE Navigator)2008-04-03
18435421Because the alpha(2C)-adrenoceptor distribution pattern is conserved between rodents and humans, studies on the role of the alpha(2C)-adrenoceptor in rodent models of neuropsychiatric disorders may be relevant also for human diseases.2010-01-21
18487435Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors.2010-01-21
18511740Observational study of gene-disease association. (HuGE Navigator)2008-06-11
18698227Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses2010-01-21
18698227Observational study of gene-disease association. (HuGE Navigator)2008-09-10
18702968Genotype and haplotype of ADRA2C did not significantly affect survival in metoprolol-treated or carvedilol-treated heart failure patients.2010-01-21
18776959Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry.2010-01-21
18776959Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-09-17
18794726Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-09-24
18835330Observational study of gene-disease association. (HuGE Navigator)2008-10-19
18835330Our findings provide important evidence that the ADRA2C polymorphism is involved in the etiology of ADHD in Korean subjects.2010-01-21
18947427Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-11-05
18947427Three polymorphisms in ADRA2C and five polymorphisms in ADRB1 were involved in eight cross-validated epistatic interactions identifying several two-locus genotype classes with significant relative risks of death/transplant in heart failure patients2010-01-21
19167638Genotype polymorphism frequencies for B1 receptor (amino acid positions 389 and 49) and alpha 2c receptor (deletion 322-325) are not significantly different in SC patients compared to female controls.2011-03-05
19309415Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-04-08
19352218Observational study of gene-disease association. (HuGE Navigator)2009-04-29
19423370Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-05-17
19423370The common ADRA2C variant affected pain perception before and after dexmedetomidine but did not affect other cognitive responses2010-04-12
19444546The ADRA2C del322-325 variant did not affect vascular sensitivity to local cold exposure.2010-01-21
19477404Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19742303Observational study of gene-disease association. (HuGE Navigator)2010-04-07
19874574Observational study of gene-disease association. (HuGE Navigator)2009-12-02
19880803Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-12-02
19880803the norepinephrine lowering and clinical therapeutic responses to bucindolol were strongly influenced by alpha(2C) receptor genotype2010-02-22
20128806The alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype.2010-07-12
20398908Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20613626Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20692245Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20705341Observational study of gene-disease association. (HuGE Navigator)2010-09-15
21041608Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-12-05
21298476alpha1b and alpha2c AR is over-expressed in basal-like breast tumours of poor prognosis2012-02-11
22040172there is little evidence for an association between alpha(2C)Del322-325 polymorphism and an increased prevalence of left ventricular hypertrophy in patients with systemic hypertension.2012-08-04
22503931the predicted signal peptide in the N-terminal tail of the alpha(2C)-adrenoceptor does not act as a cleavable signal peptide2012-09-15
22560155The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype2013-06-15
23275278Bucindolol prevents ventricular arrhythmias in subjects with heart failure and reduced left ventricular ejection fractions, and this effect is modulated by adrenergic alpha 2 receptor polymorphisms.2013-04-20
23868076the region comprising the N-terminal half of The receptors contributed to the alpha2C-selectivity of drug binding.2014-07-19
24643471Genetic variants of ADRA2C do not alter intracellular localization or plasma membrane trafficking.2015-01-31
24676565the ADRA2C 322-325I/D genotype is a novel genetic risk marker for SBI among individuals with hyperhomocysteinemia.2015-01-10
25110951alpha2C-adrenoreceptor interaction with filamin-22015-04-18
25406899Adrenergic receptor genotype influences heart failure severity and beta-blocker response in children with dilated cardiomyopathy.2015-09-26
26058836ADRA2c is associated with heart rate recovery after exercise.2016-06-04
26427149Common polymorphisms in the ADRA2C gene are not associated with orthostatic hypotension risk in Chinese.2015-10-31
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-10 of 10 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
AGAEGGAGGADGQGAGPGAAESGALTASRred-15.0351ENSP00000426268Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRred-15.0351ENSP00000426268Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRyellow-15.0351ENSP00000386069Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRyellow-15.0351ENSP00000386069Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRred-10.8351ENSP00000426268Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRred-10.8351ENSP00000426268Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRyellow-10.8351ENSP00000386069Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRyellow-10.8351ENSP00000386069Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRyellow-8.0111ENSP00000386069Proteotypic
AGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRyellow-8.0111ENSP00000386069Proteotypic
Evidence File
/mnt/mpp/ms_data/P18825_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-4 of 4 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
AGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRMaxquant143.720244482802269
ASSRSVEFFLSRMaxquant143.460245848452269
AGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRMaxquant133.130245816314269
SVEFFLSRMaxquant131.820282103512-1
Evidence File
/mnt/mpp/ms_data/P18825_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB