NEUROG2:Neurogenin-2

Gene Name
Neurogenin-2
Protein ID
Q9H2A3
Chromosome ID
4
HPP Status
2
Protein Name
Neurogenin-2
Synonyms

ngn-2

neurogenin-2

Math4A

class A basic helix-loop-helix protein 8

Class A basic helix-loop-helix protein 8

bHLHa8

NGN2

Atoh4

ATOH4

Protein atonal homolog 4

protein atonal homolog 4

neurogenin 2

BHLHA8

NGN-2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NEUROG2 ]
Chromosomal Position
4q25 | Start:112513516 End:112513516
Sequence
Q9H2A3.fasta
Description

Entrez Gene Summary for NEUROG2
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. (provided by RefSeq, Apr 2012)

UniProtKB Summary for NEUROG2
Function: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3')

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NEUROG2 ]
External IDs
Hgnc ID: 13805 EntrezGene ID: 63973 Ensembl ID: ENSG00000178403
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NEUROG2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
17784840expression of Ngn2 during the differentiation of neuronl human embryo stem cells.2010-01-21
18242186Rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in dopamine neuron differentiation.2010-01-21
19879328Novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.2010-04-12
19879328Observational study of gene-disease association. (HuGE Navigator)2009-12-02
20332099Observational study of gene-disease association. (HuGE Navigator)2010-06-30
21209909human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury2011-07-09
25403753Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.2015-02-14
25912433Study shows neurogenin 2 enhances the generation of patient-specific induced neuronal cells.2016-03-05
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9H2A3_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9H2A3_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB