RGSL1:Regulator of G-protein signaling protein-like

Gene Name
Regulator of G-protein signaling protein-like
Protein ID
A5PLK6
Chromosome ID
1
HPP Status
1
Protein Name
Regulator of G-protein signaling protein-like
Synonyms

RGSL

regulator of G-protein signaling like 1

regulator of G-protein signalling like 1

RGSL2

regulator of G-protein signaling like 2

regulator of G-protein signalling like 2

regulator of G-protein signaling protein-like


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGSL1 ]
Chromosomal Position
1q25.3 | Start:182450121 End:182450121
Sequence
A5PLK6.fasta
Description

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGSL1 ]
External IDs
Hgnc ID: 18636 EntrezGene ID: 353299 Ensembl ID: ENSG00000121446
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGSL1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
18521847A detailed mapping of the breakpoints revealed intragenic microdeletions affecting the coding regions of RGSL2, RGSL1.2010-01-21
20574532Observational study of gene-disease association. (HuGE Navigator)2010-09-15
21135262Missense mutations in RGSL1 gene is associated with breast cancer.2011-05-28
23248035Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.2013-09-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
All Reviewed HumanRGSL_HUMANRGSL_HUMAN1076107610010000110761107602239
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RGSL_HUMANIPR000342GO:0038032DomainRegulator of G protein signallingBiological Processtermination of G-protein coupled receptor signaling pathway
RGSL_HUMANIPR016137GO:0038032DomainRegulator of G protein signalling superfamilyBiological Processtermination of G-protein coupled receptor signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 54 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
NLTEVLLNTQHLEFFRgreen-14.5181ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-14.5181ENSP00000457491Proteotypic
MSFEELCYKNPKgreen-13.9241ENSP00000457491Proteotypic
MSFEELCYKNPKgreen-13.9241ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-13.3181ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-13.3181ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-12.3181ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-12.3181ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.8141ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.8141ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.5141ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.5141ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.0141ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-11.0141ENSP00000457491Proteotypic
RQEFEDYLHQEMQNSKgreen-10.261ENSP00000457491Proteotypic
RQEFEDYLHQEMQNSKgreen-10.261ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-10.0141ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-10.0181ENSP00000457491Proteotypic
NLTEVLLNTQHLEFFRgreen-10.0181ENSP00000457491Proteotypic
HVTTSTLLTLQGHVMKgreen-10.0141ENSP00000457491Proteotypic
Evidence File
/mnt/mpp/ms_data/A5PLK6_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-6 of 6 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
SLIENVIK0.00271840464951632,Mascot:expectation;47.55,Mascot:score;PXD000039_27330_26414_A5PLK6_SLIENVIKPXD000039;PRIDE_Exp_Complete_Ac_27330.xml;spectrum=26414
SLIENVIK0.00271840464951632,Mascot:expectation;47.55,Mascot:score;PXD000039_27330_26414_A5PLK6_SLIENVIKPXD000039;PRIDE_Exp_Complete_Ac_27330.xml;spectrum=26414
SLIENVIK0.0188024809034383,Mascot:expectation;41.03,Mascot:score;PXD000039_27331_26946_A5PLK6_SLIENVIKPXD000039;PRIDE_Exp_Complete_Ac_27331.xml;spectrum=26946
SLIENVIK0.0188024809034383,Mascot:expectation;41.03,Mascot:score;PXD000039_27331_26946_A5PLK6_SLIENVIKPXD000039;PRIDE_Exp_Complete_Ac_27331.xml;spectrum=26946
SLIENVIK0.0188024809034383,Mascot:expectation;41.03,Mascot:score;PXD000039_27331_26946_A5PLK6_SLIENVIKPXD000039;PRIDE_Exp_Complete_Ac_27331.xml;spectrum=26946
IDFKMEII10.05,Spectrum Mill peptide score;PRD000118_10530_15_A5PLK6_IDFKMEIIPRD000118;PRIDE_Exp_Complete_Ac_10530.xml;spectrum=15
Evidence File
/mnt/mpp/ms_data/A5PLK6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-2 of 2 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
KSQTIQGLMaxquant126.280779922673279
IDFKMEIIKMaxquant123.980187468861
Evidence File
/mnt/mpp/ms_data/A5PLK6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB