RASL11A:Ras-like protein family member 11A

Gene Name
Ras-like protein family member 11A
Protein ID
Q6T310
Chromosome ID
13
HPP Status
2
Protein Name
Ras-like protein family member 11A
Synonyms

RAS-like, family 11, member A

ras-like protein family member 11A


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
Chromosomal Position
13q12.2 | Start:27270327 End:27270327
Sequence
Q6T310.fasta
Description

Entrez Gene Summary for RASL11A
RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.(supplied by OMIM, Nov 2008)

UniProtKB Summary for RASL11A
Function: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
External IDs
Hgnc ID: 23802 EntrezGene ID: 387496 Ensembl ID: ENSG00000122035
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15033445RASL11A is down-regulated in prostate tumors as measured by quantitative real-time PCR. This result suggests that this gene may have a tumor suppressor role in prostate cancer.2004-03-24
20168301In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region.2010-05-10
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceRSLBA_HUMANRSLBA_MOUSE24224289.26100260124212424.00E-117416
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RSLBA_HUMANIPR001806GO:0005525FamilySmall GTPase superfamilyMolecular FunctionGTP binding
RSLBA_HUMANIPR001806GO:0007264FamilySmall GTPase superfamilyBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003578GO:0005525FamilySmall GTPase superfamily, Rho typeMolecular FunctionGTP binding
RSLBA_HUMANIPR003578GO:0005622FamilySmall GTPase superfamily, Rho typeCellular Componentintracellular
RSLBA_HUMANIPR003578GO:0007264FamilySmall GTPase superfamily, Rho typeBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003579GO:0005525FamilySmall GTPase superfamily, Rab typeMolecular FunctionGTP binding
RSLBA_HUMANIPR003579GO:0007264FamilySmall GTPase superfamily, Rab typeBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003579GO:0015031FamilySmall GTPase superfamily, Rab typeBiological Processprotein transport
RSLBA_HUMANIPR005225GO:0005525DomainSmall GTP-binding protein domainMolecular FunctionGTP binding
RSLBA_HUMANIPR020849GO:0003924FamilySmall GTPase superfamily, Ras typeMolecular FunctionGTPase activity
RSLBA_HUMANIPR020849GO:0005525FamilySmall GTPase superfamily, Ras typeMolecular FunctionGTP binding
RSLBA_HUMANIPR020849GO:0006184FamilySmall GTPase superfamily, Ras typeBiological ProcessGTP catabolic process
RSLBA_HUMANIPR020849GO:0007165FamilySmall GTPase superfamily, Ras typeBiological Processsignal transduction
RSLBA_HUMANIPR020849GO:0016020FamilySmall GTPase superfamily, Ras typeCellular Componentmembrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q6T310_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q6T310_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB