RASL11A:Ras-like protein family member 11A

Gene Name
Ras-like protein family member 11A
Protein ID
Chromosome ID
HPP Status
Protein Name
Ras-like protein family member 11A

RAS-like, family 11, member A

ras-like protein family member 11A

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
Chromosomal Position
13q12.2 | Start:27270327 End:27270327

Entrez Gene Summary for RASL11A
RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.(supplied by OMIM, Nov 2008)

UniProtKB Summary for RASL11A
Function: Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
External IDs
Hgnc ID: 23802 EntrezGene ID: 387496 Ensembl ID: ENSG00000122035
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASL11A ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
15033445RASL11A is down-regulated in prostate tumors as measured by quantitative real-time PCR. This result suggests that this gene may have a tumor suppressor role in prostate cancer.2004-03-24
20168301In transient transfection experiments, RasL11a enhanced the transcriptional activity of an RNA polymerase I-specific reporter controlled by the rDNA enhancer/promoter region.2010-05-10


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceRSLBA_HUMANRSLBA_MOUSE24224289.26100260124212424.00E-117416
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RSLBA_HUMANIPR001806GO:0005525FamilySmall GTPase superfamilyMolecular FunctionGTP binding
RSLBA_HUMANIPR001806GO:0007264FamilySmall GTPase superfamilyBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003578GO:0005525FamilySmall GTPase superfamily, Rho typeMolecular FunctionGTP binding
RSLBA_HUMANIPR003578GO:0005622FamilySmall GTPase superfamily, Rho typeCellular Componentintracellular
RSLBA_HUMANIPR003578GO:0007264FamilySmall GTPase superfamily, Rho typeBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003579GO:0005525FamilySmall GTPase superfamily, Rab typeMolecular FunctionGTP binding
RSLBA_HUMANIPR003579GO:0007264FamilySmall GTPase superfamily, Rab typeBiological Processsmall GTPase mediated signal transduction
RSLBA_HUMANIPR003579GO:0015031FamilySmall GTPase superfamily, Rab typeBiological Processprotein transport
RSLBA_HUMANIPR005225GO:0005525DomainSmall GTP-binding protein domainMolecular FunctionGTP binding
RSLBA_HUMANIPR020849GO:0003924FamilySmall GTPase superfamily, Ras typeMolecular FunctionGTPase activity
RSLBA_HUMANIPR020849GO:0005525FamilySmall GTPase superfamily, Ras typeMolecular FunctionGTP binding
RSLBA_HUMANIPR020849GO:0006184FamilySmall GTPase superfamily, Ras typeBiological ProcessGTP catabolic process
RSLBA_HUMANIPR020849GO:0007165FamilySmall GTPase superfamily, Ras typeBiological Processsignal transduction
RSLBA_HUMANIPR020849GO:0016020FamilySmall GTPase superfamily, Ras typeCellular Componentmembrane
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB