GPR18:N-arachidonyl glycine receptor

Gene Name
N-arachidonyl glycine receptor
Protein ID
Q14330
Chromosome ID
13
HPP Status
2
Protein Name
N-arachidonyl glycine receptor
Synonyms

N-arachidonyl glycine receptor

GPCRW

G-protein coupled receptor 18

NAGly receptor

G protein-coupled receptor 18


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR18 ]
Chromosomal Position
13q32.3 | Start:99254714 End:99254714
Sequence
Q14330.fasta
Description

UniProtKB Summary for GPR18
Function: Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR18 ]
External IDs
Hgnc ID: 4472 EntrezGene ID: 2841 Ensembl ID: ENSG00000125245
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR18 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
16844083N-arachidonylglycine is a natural ligand for GPR182010-01-21
20880198GPR18, the most abundantly overexpressed orphan G-protein-coupled receptor in all melanoma metastases, is constitutively active and inhibits apoptosis, indicating an important role for GPR18 in tumor cell survival.2011-04-23
21261596REVIEW: functional properties and in vivo biology2011-09-17
24762058the results presented herein provide further evidence for GPR18 as a candidate cannabinoid receptor2015-04-11
26195725A novel RvD2-GPR18 resolution axis stimulates human and mouse phagocyte functions to control bacterial infections and promote organ protection.2015-10-31
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
GPR18_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
GPR18_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
GPR18_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q14330_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q14330_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive