PCDH20:Protocadherin-20

Gene Name
Protocadherin-20
Protein ID
Q8N6Y1
Chromosome ID
13
HPP Status
2
Protein Name
Protocadherin-20
Synonyms

protocadherin 20

protocadherin-20

Protocadherin-13

protocadherin 13

PCDH13

protocadherin-13


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PCDH20 ]
Chromosomal Position
13q21.2 | Start:61409685 End:61409685
Sequence
Q8N6Y1.fasta
Description

Entrez Gene Summary for PCDH20
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. (provided by RefSeq, Jul 2008)

UniProtKB Summary for PCDH20
Function: Potential calcium-dependent cell-adhesion protein

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PCDH20 ]
External IDs
Hgnc ID: 14257 EntrezGene ID: 64881 Ensembl ID: ENSG00000197991
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PCDH20 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
24910204In conclusion, these data here strongly suggested that PCDH20 may act as a candidate tumour suppressor in hepatocellular carcinoma.2015-10-10
25736877Study shows that PCDH20 expression is downregulated in nasopharyngeal carcinoma cells (NPC) and identified it as a functional tumor suppressor and an important antagonist of Wnt/beta-catenin signaling and EMT, with frequent epigenetic inactivation in NPC.2016-04-09
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
PCD20_HUMANIPR002126GO:0005509DomainCadherinMolecular Functioncalcium ion binding
PCD20_HUMANIPR002126GO:0007156DomainCadherinBiological Processhomophilic cell adhesion
PCD20_HUMANIPR002126GO:0016020DomainCadherinCellular Componentmembrane
PCD20_HUMANIPR015919GO:0005509DomainCadherin-likeMolecular Functioncalcium ion binding
PCD20_HUMANIPR015919GO:0016020DomainCadherin-likeCellular Componentmembrane
PCD20_HUMANIPR020894GO:0005886Conserved_siteCadherin conserved siteCellular Componentplasma membrane
PCD20_HUMANIPR020894GO:0007155Conserved_siteCadherin conserved siteBiological Processcell adhesion
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-2 of 2 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
ATELLYSLNEGLPAGVLIGSLAEDLRLLPRgreen-7.451ENSP00000386653Proteotypic
ATELLYSLNEGLPAGVLIGSLAEDLRLLPRgreen-7.451ENSP00000386653Proteotypic
Evidence File
/mnt/mpp/ms_data/Q8N6Y1_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8N6Y1_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-5 of 5 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
SGELHTSAQEIDRMaxquant194.8601354555006-1
SAGRPDPQSQLPERMaxquant185.3201317754298-1
PESFRIDPKMaxquant140.1407908557512297
LAIEHPAVDPDVGINGVQTYRMaxquant132.7901333374514-1
DLFHLDENTGVIKMaxquant124.0701357331588-1
Evidence File
/mnt/mpp/ms_data/Q8N6Y1_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB