CORT:Cortistatin

Gene Name
Cortistatin
Protein ID
O00230
Chromosome ID
1
HPP Status
2
Protein Name
Cortistatin
Synonyms

cortistatin-17

cortistatin-14

CST-29

cortistatin-29

prepro-cortistatin

"prepro-cortistatin"

cortistatin

CST-14

preprocortistatin

CST-17


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CORT ]
Chromosomal Position
1p36.22 | Start:10449719 End:10449719
Sequence
O00230.fasta
Description

Entrez Gene Summary for CORT
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. (provided by RefSeq, Nov 2010)

UniProtKB Summary for CORT
Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CORT ]
External IDs
Hgnc ID: 2257 EntrezGene ID: 1325 Ensembl ID: ENSG00000241563
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CORT ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
10461921Identifies post-translational cleavage products of the homologous rat protein.2010-11-10
12161511Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.2010-01-21
12519865first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 receptor in the immune system2010-01-21
12684217study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2, in human monocyte-derived cells2010-01-21
12915402cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion2010-01-21
14669820Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas2010-01-21
16043736Intravitreous somatostatin-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy.2010-01-21
18450367Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. [review]2010-01-21
18709137A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration.2010-01-21
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
20164562The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed.2010-09-13
20398908Observational study of gene-disease association. (HuGE Navigator)2010-06-30
23595952Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation.2013-07-27
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianCORT_HUMANCORT_RAT1058256.178.134124105331129.00E-2092
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CORT_HUMANIPR018142GO:0005179DomainSomatostatin/Cortistatin, C-terminalMolecular Functionhormone activity
CORT_HUMANIPR018142GO:0005576DomainSomatostatin/Cortistatin, C-terminalCellular Componentextracellular region
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-2 of 2 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
DSEHMQEAAGIRred-9.721ENSP00000366248Proteotypic
DSEHMQEAAGIRred-9.721ENSP00000366248Proteotypic
Evidence File
/mnt/mpp/ms_data/O00230_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O00230_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB