SOHLH2:Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

Gene Name
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Protein ID
Q9NX45
Chromosome ID
13
HPP Status
2
Protein Name
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Synonyms

TEB1

bHLHe81

SPATA28

"spermatogenesis associated 28"

spermatogenesis associated 28

spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

spermatogenesis and oogenesis specific basic helix-loop-helix 2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SOHLH2 ]
Chromosomal Position
13q13.3 | Start:36168208 End:36168208
Sequence
Q9NX45.fasta
Description

Entrez Gene Summary for SOHLH2
This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2013)

UniProtKB Summary for SOHLH2
Function: Probable transcription factor, which may be involved in spermatogenesis and oogenesis (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SOHLH2 ]
External IDs
Hgnc ID: 26026 EntrezGene ID: 54937 Ensembl ID: ENSG00000120669
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SOHLH2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19834535Observational study of gene-disease association. (HuGE Navigator)2009-12-02
24524832Our identification of novel variants in the SOHLH2 gene, in women with POF of both Chinese and Serbian origin, strongly suggests an important role for SOHLH2 in human POF etiology.2014-06-07
24858206Low Sohlh2 expression is associated with ovarian cancer.2015-02-21
25463635The polymorphisms rs1328626 and rs6563386 of the SOHLH2 gene would be the genetic risk factors for nonobstructive azoospermia in the Chinese population. The SNP rs1328641 might influence testes development in the NOA patients.2015-09-05
26375665the expression of Sohlh genes in human tissues2016-05-28
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceSOLH2_HUMANSOLH2_MOUSE42542051.998.821993141914182E-115412
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SOLH2_HUMANIPR011598GO:0046983DomainMyc-type, basic helix-loop-helix (bHLH) domainMolecular Functionprotein dimerization activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-2 of 2 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
SYSEHLGYFPTDLFACSESLRred-11.6101ENSP00000326838Proteotypic
SYSEHLGYFPTDLFACSESLRred-11.6101ENSP00000326838Proteotypic
Evidence File
/mnt/mpp/ms_data/Q9NX45_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/Q9NX45_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9NX45_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive