GUCY1B2:Guanylate cyclase soluble subunit beta-2

Gene Name
Guanylate cyclase soluble subunit beta-2
Protein ID
O75343
Chromosome ID
13
HPP Status
2
Protein Name
Guanylate cyclase soluble subunit beta-2
Synonyms

guanylate cyclase 1, soluble, beta 2 (pseudogene)

GCS-beta-2

guanylate cyclase 1, soluble, beta 2

GC-SB2

EC 4.6.1.2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GUCY1B2 ]
Chromosomal Position
13q14.3 | Start:50994511 End:50994511
Sequence
O75343.fasta
Description

Tocris Summary for GUCY1B2
Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases. There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GUCY1B2 ]
External IDs
Hgnc ID: 4686 EntrezGene ID: 2974 Ensembl ID: ENSG00000123201
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=GUCY1B2 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceGCYB2_HUMANANPRA_RAT61721251.8934.3699335656483710482.00E-53206
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
GCYB2_HUMANIPR001054GO:0009190DomainAdenylyl cyclase class-3/4/guanylyl cyclaseBiological Processcyclic nucleotide biosynthetic process
GCYB2_HUMANIPR001054GO:0016849DomainAdenylyl cyclase class-3/4/guanylyl cyclaseMolecular Functionphosphorus-oxygen lyase activity
GCYB2_HUMANIPR001054GO:0035556DomainAdenylyl cyclase class-3/4/guanylyl cyclaseBiological Processintracellular signal transduction
GCYB2_HUMANIPR011644GO:0020037DomainHeme-NO bindingMolecular Functionheme binding
GCYB2_HUMANIPR011645GO:0004383DomainHaem NO binding associatedMolecular Functionguanylate cyclase activity
GCYB2_HUMANIPR011645GO:0006182DomainHaem NO binding associatedBiological ProcesscGMP biosynthetic process
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00230KEGG PATHWAYPurine metabolism
hsa04270KEGG PATHWAYVascular smooth muscle contraction
hsa04540KEGG PATHWAYGap junction
hsa04730KEGG PATHWAYLong-term depression
hsa04970KEGG PATHWAYSalivary secretion
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O75343_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/O75343_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O75343_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive