AGBL4:Cytosolic carboxypeptidase 6

Gene Name
Cytosolic carboxypeptidase 6
Protein ID
Q5VU57
Chromosome ID
1
HPP Status
2
Protein Name
Cytosolic carboxypeptidase 6
Synonyms

CCP6

cytosolic carboxypeptidase 6

ATP/GTP-binding protein-like 4

ATP/GTP binding protein-like 4

EC 3.4.17.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AGBL4 ]
Chromosomal Position
1p33 | Start:48532855 End:48532855
Sequence
Q5VU57.fasta
Description

UniProtKB Summary for AGBL4
Function: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AGBL4 ]
External IDs
Hgnc ID: 25892 EntrezGene ID: 84871 Ensembl ID: ENSG00000186094
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AGBL4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19240061Observational study of gene-disease association. (HuGE Navigator)2009-04-01
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
25416787Nna1 and CCP4 remove the C-terminal glutamate from substrates with two or more glutamates, whereas CCP6 requires four or more glutamates. CCP4 behaves as a promiscuous glutamase with little preference for chain length or neighboring amino acid composition2015-04-25
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceCBPC6_HUMANCBPC6_MOUSE50347490.5194.23381147414670.00E+00911
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CBPC6_HUMANIPR000834GO:0004181DomainPeptidase M14, carboxypeptidase AMolecular Functionmetallocarboxypeptidase activity
CBPC6_HUMANIPR000834GO:0006508DomainPeptidase M14, carboxypeptidase ABiological Processproteolysis
CBPC6_HUMANIPR000834GO:0008270DomainPeptidase M14, carboxypeptidase AMolecular Functionzinc ion binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q5VU57_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q5VU57_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q5VU57_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB