KLHL1:Kelch-like protein 1

Gene Name
Kelch-like protein 1
Protein ID
Q9NR64
Chromosome ID
13
HPP Status
2
Protein Name
Kelch-like protein 1
Synonyms

kelch-like 1 (Drosophila)

MRP2

"Kelch-like protein 1"

KIAA1490

kelch-like protein 1

Mayven-related protein 2

kelch (Drosophila)-like 1

"Mayven-related protein 2"

kelch-like family member 1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1 ]
Chromosomal Position
13q21.33 | Start:69700594 End:69700594
Sequence
Q9NR64.fasta
Description

Entrez Gene Summary for KLHL1
The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000 (PubMed 10888605)).(supplied by OMIM, Feb 2010)

UniProtKB Summary for KLHL1
Function: May play a role in organizing the actin cytoskeleton of the brain cells

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1 ]
External IDs
Hgnc ID: 6352 EntrezGene ID: 57626 Ensembl ID: ENSG00000150361
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLHL1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
16982692This study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner.2010-01-21
17289272modulatory effect of KLHL1 on the P/Q-type calcium channel function, suggesting a possible novel role for KLHL1 in cellular excitability.2010-01-21
18708037KLHL1 was expressed in human brain and kidney, but was also in other tissues, such as prostate gland, small intestine, colon, testis (but not the ovaries), liver and pancreas.2010-01-21
20147652KLHL1 interacts with Cav3.2 and modulates T-type calcium currents by increasing current deactivation kinetics and current density and calcium influx.2010-06-28
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
21427078Renal transplant recipients T carriers of C24T MRP2 with macrolides treatment were associated with reduced mycophenolic acid area under curve in steady-state conditions2012-06-02
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceKLHL1_HUMANKLHL1_MOUSE74875195.21100.4332174817510.00E+001326
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
KLHL1_HUMANIPR000210GO:0005515DomainBTB/POZ-likeMolecular Functionprotein binding
KLHL1_HUMANIPR006652GO:0005515RepeatKelch repeat type 1Molecular Functionprotein binding
KLHL1_HUMANIPR013069GO:0005515DomainBTB/POZMolecular Functionprotein binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9NR64_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/Q9NR64_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9NR64_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive