ADORA3:Adenosine receptor A3

Gene Name
Adenosine receptor A3
Protein ID
Chromosome ID
HPP Status
Protein Name
Adenosine receptor A3

adenosine receptor A3


adenosine A3 receptor



[Reference: ]
Chromosomal Position
1p13.2 | Start:111499429 End:111499429

Entrez Gene Summary for ADORA3
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ADORA3
Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity)|Function: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction

Tocris Summary for ADORA3
The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion. The human A3 receptor gene is localized on chromosome 1 (1p21-p13).

[Reference: ]
External IDs
Hgnc ID: 268 EntrezGene ID: 140 Ensembl ID: ENSG00000121933
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Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
11891221identification of residues in ligand recognition and activation2010-01-21
12152652involvement in adenosine inhibition of tissue factor expression by LPS-stimulated human monocytes2010-01-21
12406340adenosine triggers a survival signal via A3 receptor activation and it kills the cell through A2A receptor inducing a signaling pathway that involves protein kinase C and mitogen-activated protein kinases.2010-01-21
12435805A(3) receptors, in astrocytoma cells, are regulated after short- and long-term agonist exposure.2010-01-21
12600879Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.2010-01-21
12695530using a rhodopsin-based molecular model of the A(3)AR to suggest multiple binding modes of the allosteric modulators.2010-01-21
14688204how RhoA activates phospholipase D to achieve the anti-ischemic effect of adenosine A3 receptors2010-01-21
14978250an in-depth investigation of A3 receptors in human lymphocytes and demonstrate that, under activating conditions, they are up-regulated and may contribute to the effects triggered by adenosine.2010-01-21
15147729effects of an A3AR agonist, IB-MECA, on the cell growth of human breast cancer cell lines suggest that the inhibitory effect of on the growth of human breast cancer cell lines is mediated through activation of A3 adenosine receptor.2010-01-21
15240539A(3)AR is expressed in tumors and may have a role in disease progression2010-01-21
15355922Elevated expression of A3 adenosine receptors is associated with colorectal cancer2010-01-21
15849244biophysical analysis of the effect of surfactants on human adenosine a3 receptor2010-01-21
16242072A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-22010-01-21
16282197These data suggest that hypertonic saline upregulates polymorphonuclear neutrophil degranulation via ATP release and positive feedback through P2 and A3 receptors.2010-01-21
16849509Modulation of the adenosine A3 receptor on cord blood mononuclear cells polarizes toll- like receptor-mediated cytokine production during the perinatal period and may thereby modulate the newborn innate and adaptive immune responses.2010-01-21
17170310ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils2010-01-21
17216675Overexpression of A3AR was found in PBMC of RA patients. Receptor upregulation was induced by inflammatory cytokines controlling the expression of the A3AR transcription factor NF-kappaB2010-01-21
17348028in colon cancer cell lines endogenous adenosine, through the interaction with A(3) receptors, mediates a tonic proliferative effect2010-01-21
17728764Genetic variants in the adenosine A1/A3 receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.2010-01-21
17728764Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18351132our findings revealed the role of adenosine receptors in breast cancer cell lines on growth modulation role of A3 and functional form of A2B, although its involvement in cell growth modulation was not seen2010-01-21
18636149The A3 adenosine receptor is highly expressed in hepatocellular carcinoma (HCC)patients and might be a novel targeted therapy to treat HCC.2010-01-21
18653544Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages.2010-01-21
18996102Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-03-25
19019667Observational study of gene-disease association. (HuGE Navigator)2008-12-03
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19095736when PBMC were stimulated with IFN-alpha, adenosine did not decrease, but synergistically increased, the IFN-gamma production of NK cells. This effect was also mediated mainly via the A(3) receptor2010-01-21
19426966NF-kappaB and CREB are involved with the over-expression of A(3)AR in patients with autoimmune inflammatory diseases. The receptor may be considered as a specific target to combat inflammation.2010-01-21
19794965Data suggest that adenosine receptor modulation may be useful for refining the use of chemotherapeutic drugs to treat human cancer more effectively.2010-01-21
19883624Studies indicate that adenosine mediates its actions by means of activation of specifiic G protein-coupled receptors, for which 4 subbtypes: A1R, A2AR, A2BR and A3R have2010-04-12
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20190146we show that A3 adenosine receptor/Gi3 play important roles in human mast cells responses initiated on contact with activated T cells.2010-05-03
20237496Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20602615Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
20716228Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20716228results suggest that the high-transcript haplotype, ht1 (TC), of the ADORA3 gene may contribute to the development of cutaneous hyper-reactivity to aspirin, leading to the clinical presentation of aspirin-induced urticaria.2011-01-15
20732875testicular mouse A3Ri2 and human A3Ri3 adenosine receptors have roles in sperm function2010-11-27
21542986ADORA3 was expressed weakly in the cytoplasm of retinal pigment epithelium.2011-10-01
21675873single-nucleotide polymorphism (SNP) I248L (reference SNP ID: rs35511654) located in the A3R gene is associated with coronary heart disease2011-12-24
21715680This study provides new insight into the spatial and temporal specificity of drug action that can be provided by allosteric modulation across a GPCR homodimeric interface.2011-12-10
21830157control of prostate cancer cell growth through A3 adenosine receptor activation.2011-11-12
21841534A3 receptor expression on the surface of PMNs is upregulated by injury, and increased expression levels are associated with greater injury severity and hypovolemic shock.2012-05-19
22146575Data show that A2A and A3 adenosine receptor density inversely correlated with Disease Activity Score in 28 or 44 joints (DAS28 or DAS) suggesting a direct role of the endogenous activation of these receptors in the control of RA joint inflammation.2012-12-22
22217884adenosine stimulates human endothelial progenitor cells migration by activating AA and A receptors and provides evidence to support a role of adenosine in modulating angiogenic capacity of hEPC2012-09-22
22378888Inactivation of the ADORA3 receptor prevents the CXCL16 effect of neuroprotection against excitotoxic damage.2012-04-21
22682496There is differential expression of receptors in rheumatoid synovial tissue such that ADORA3 is expressed at significantly higher levels2013-05-25
22906537Activation of smooth muscle adenosine A(3) receptors increase proliferation of human coronary smooth cells.2013-03-23
23027555A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses.2013-02-16
23817552Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.2013-10-26
23856527This is a review of the role played by A2aR and A3AR in regulating cancer pathogenesis, with a focus on melanoma, and the therapeutic potential of adenosine receptors pharmacological modulation. [review]2014-04-19
24161786Different agonistic behavior at adenosine A3 receptor is linked to a sub-pocket of the binding site.2014-03-22
24750014Effect of a toggle switch mutation in TM6 of the human adenosine A receptor on Gi protein-dependent signalling and Gi-independent receptor internalization2015-04-11
25597247This study identifies human mast cell A3R as regulator of tissue remodeling gene expression in human mast cells and demonstrates a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor.2015-05-02
26194548Differential regulation in patients with LTP-induced anaphylaxis and those with NSAID-LTP-induced anaphylaxis of the IFN-gamma pathway, IgG receptors, and ADORA3 might provide the pathogenic basis of their distinct responses2016-05-28


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM