POU4F1:POU domain, class 4, transcription factor 1

Gene Name
POU domain, class 4, transcription factor 1
Protein ID
Chromosome ID
HPP Status
Protein Name
POU domain, class 4, transcription factor 1



brain-specific homeobox/POU domain protein 3A


POU domain class 4, transcription factor 1


Homeobox/POU domain protein RDC-1

POU class 4 homeobox 1



Brain-specific homeobox/POU domain protein 3A

homeobox/POU domain protein RDC-1

POU domain, class 4, transcription factor 1



[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU4F1 ]
Chromosomal Position
13q31.1 | Start:78598362 End:78598362

Entrez Gene Summary for POU4F1
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. (provided by RefSeq, Mar 2012)

UniProtKB Summary for POU4F1
Function: Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU4F1 ]
External IDs
Hgnc ID: 9218 EntrezGene ID: 5457 Ensembl ID: ENSG00000152192
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU4F1 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
12427558genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus2010-01-21
12893201Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap smear.2010-01-21
12911730These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.2010-01-21
15021903oncogenic rearrangement of EWS to produce EWS/Fli-1 may enhance the antiapoptotic effect of Brn-3a and inhibit its ability to promote neuronal differentiation.2010-01-21
15272315Hsp27 expression and cell survival are regulated by the POU transcription factor Brn3a2010-01-21
16247485Brn-3a has a role in differential regulation of different human papilloma virus variants2010-01-21
16276351Upregulation of Brn-3a is associated with prostate cancer2010-01-21
20348952Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner.2010-07-12
20376082Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia.2010-06-14
21928122BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells.2011-12-17
22064348PoU4F1 is highly expressed in t(8;21) samples, with AML/ETO appearning to promote some BRN3A expression2012-07-07
22930747Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.2013-04-13
23666755Brn3a cooperates with activated RAS/RAF signalling by reducing oncogene-induced senescence in melanocytic tumourigenesis.2013-11-16


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidencePO4F1_HUMANPO3F3_RAT41915651.9237.236932604133104613.00E-38155
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
PO4F1_HUMANIPR000327GO:0003700DomainPOU-specificMolecular Functionsequence-specific DNA binding transcription factor activity
PO4F1_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
PO4F1_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
PO4F1_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
PO4F1_HUMANIPR010982GO:0003677DomainLambda repressor-like, DNA-binding domainMolecular FunctionDNA binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB