IFNE:Interferon epsilon

Gene Name
Interferon epsilon
Protein ID
Q86WN2
Chromosome ID
9
HPP Status
2
Protein Name
Interferon epsilon
Synonyms

IFNE1

interferon epsilon 1

PRO655

interferon, epsilon

INFE1

IFN-epsilon

Interferon epsilon-1

interferon-epsilon

interferon tau-1

interferon epsilon-1

interferon epsilon

IFNT1

IFN-E


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNE ]
Chromosomal Position
9p21.3 | Start:21480839 End:21480839
Sequence
Q86WN2.fasta
Description

UniProtKB Summary for IFNE
Function: Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNE ]
External IDs
Hgnc ID: 18163 EntrezGene ID: 338376 Ensembl ID: ENSG00000184995
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNE ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15233997The structue and mRNA expression pattern of IFN-epsilon1 suggest that it may have a function distinct from those other members of type I INF.2010-01-21
17878351TNF-alpha leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased STAT1 expression and phosphorylation, and up-regulation of retinoic acid-inducible gene-I expression2010-01-21
18362232A meta-analysis and a single-nucleotide polymorphism (SNP) rs1333049 representing the 9p21.3 locus provide unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of coronary artery disease.2010-01-21
18842358In macrophages IFN-tau increased the synthesis of 2',5'-oligoadenylate synthetase/RNase L, MxA protein, IL-10 & IL-6, but not of IL-1ss or TNF-alpha.2010-01-21
20574843Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20588308Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20601674Observational study of gene-disease association. (HuGE Navigator)2010-09-15
23802172genetic polymorphism is related to onset time of vitiligo in Korean patients2014-02-15
23851686Full-length IFN-epsilon 5'UTR markedly suppressed mRNA expression under basal conditions. It contains 2 stable stem-loop structures which associate with importin 9. Loop 1 is essential for regulation of mRNA expression.2014-03-22
24055696T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.2014-08-09
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceIFNE_HUMANIFNE_MOUSE20818959.2690.87761118911881E-59224
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
IFNE_HUMANIPR000471GO:0005126FamilyInterferon alpha/beta/deltaMolecular Functioncytokine receptor binding
IFNE_HUMANIPR000471GO:0005576FamilyInterferon alpha/beta/deltaCellular Componentextracellular region
IFNE_HUMANIPR000471GO:0006952FamilyInterferon alpha/beta/deltaBiological Processdefense response
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04060KEGG PATHWAYCytokine-cytokine receptor interaction
hsa04622KEGG PATHWAYRIG-I-like receptor signaling pathway
hsa04630KEGG PATHWAYJak-STAT signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q86WN2_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q86WN2_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q86WN2_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB