WNT9A:Protein Wnt-9a

Gene Name
Protein Wnt-9a
Protein ID
O14904
Chromosome ID
1
HPP Status
2
Protein Name
Protein Wnt-9a
Synonyms

Protein Wnt-14

WNT14

wingless-type MMTV integration site family, member 9A

wingless-type MMTV integration site family, member 14

protein Wnt-9a


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=WNT9A ]
Chromosomal Position
1q42.13 | Start:227918656 End:227918656
Sequence
O14904.fasta
Description

Entrez Gene Summary for WNT9A
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. (provided by RefSeq, Jul 2008)

UniProtKB Summary for WNT9A
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=WNT9A ]
External IDs
Hgnc ID: 12778 EntrezGene ID: 7483 Ensembl ID: ENSG00000143816
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=WNT9A ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11836627Found clustered with WNT3A on 1q42. .2010-01-21
158097695'-flanking promoter region was significantly divergent between human WNT9A and rodent Wnt9a genes.2010-01-21
17351820These results suggests the expression level of human Wnt9a in MCF-7 that breast cancer may play a role in adjusting the rate of cellular proliferation.2010-01-21
17429723cDNA gene expression array of Wnt signaling pathway target genes demonstrated significant changes, including 4.5-fold induction of Wnt 9A and suppression of Dickkopf 3 and RHOU genes.2010-01-21
19453261Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19863181Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects.2010-03-29
20613673Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20854080Using DirectDNA sequencing analysis, we detected ATBF1, CYLD, PARK2 and WNT9A mutations in stomach and colorectal cancers2011-01-08
23154410Transgenic wnt9a is required for palatal extension wherein the chondrocytes form a proliferative front, undergo morphological change and intercalate to form the ethmoid plate.2013-02-02
24778176These studies reveal how carrageenan exposure can lead to transcriptional events in colonic epithelial cells through decline in arylsulfatase B activity, with subsequent impact on C4S, galectin-3, Sp1, and Wnt9A2014-10-11
25511584Silencing Wnt9A increased the expression of CHST11 in the colonic epithelial cells, and chromatin immunoprecipitation assay demonstrated enhancing effects of Wnt9A siRNA and exogenous BMP4 on the CHST11 promoter2015-08-29
26174360expression is enhanced in idiopathic carpal tunnel syndrome2015-11-28
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
WNT9A_HUMANIPR005817GO:0005102FamilyWntMolecular Functionreceptor binding
WNT9A_HUMANIPR005817GO:0005576FamilyWntCellular Componentextracellular region
WNT9A_HUMANIPR005817GO:0007275FamilyWntBiological Processmulticellular organismal development
WNT9A_HUMANIPR005817GO:0016055FamilyWntBiological ProcessWnt receptor signaling pathway
WNT9A_HUMANIPR013303GO:0005102FamilyWnt-9a proteinMolecular Functionreceptor binding
WNT9A_HUMANIPR013303GO:0005576FamilyWnt-9a proteinCellular Componentextracellular region
WNT9A_HUMANIPR013303GO:0007275FamilyWnt-9a proteinBiological Processmulticellular organismal development
WNT9A_HUMANIPR013303GO:0016055FamilyWnt-9a proteinBiological ProcessWnt receptor signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04310KEGG PATHWAY@@Wnt signaling pathway
hsa04340KEGG PATHWAYHedgehog signaling pathway
hsa04916KEGG PATHWAYMelanogenesis
hsa05166KEGG PATHWAYHTLV-I infection
hsa05200KEGG PATHWAYPathways in cancer
hsa05217KEGG PATHWAYBasal cell carcinoma
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-8 of 8 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
WNCTLEGRgreen-8.151ENSP00000272164Proteotypic
WNCTLEGRgreen-8.151ENSP00000272164Proteotypic
WNCTLEGRgreen-7.051ENSP00000272164Proteotypic
WNCTLEGRgreen-7.051ENSP00000272164Proteotypic
WNCTLEGRgreen-6.551ENSP00000272164Proteotypic
WNCTLEGRgreen-6.551ENSP00000272164Proteotypic
WNCTLEGRgreen-6.451ENSP00000272164Proteotypic
WNCTLEGRgreen-6.451ENSP00000272164Proteotypic
Evidence File
/mnt/mpp/ms_data/O14904_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O14904_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O14904_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB