BMP8A:Bone morphogenetic protein 8A

Gene Name
Bone morphogenetic protein 8A
Protein ID
Q7Z5Y6
Chromosome ID
1
HPP Status
2
Protein Name
Bone morphogenetic protein 8A
Synonyms

BMP-8A

bone morphogenetic protein 8A

bone morphogenetic protein 8a


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP8A ]
Chromosomal Position
1p34.3 | Start:39491646 End:39491646
Sequence
Q7Z5Y6.fasta
Description

UniProtKB Summary for BMP8A
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP8A ]
External IDs
Hgnc ID: 21650 EntrezGene ID: 353500 Ensembl ID: ENSG00000183682
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMP8A ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20237496Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20424473Observational study of gene-disease association. (HuGE Navigator)2010-06-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceBMP8A_HUMANBMP8B_MOUSE40236474.1890.5592139402383992.00E-141498
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
BMP8A_HUMANIPR001111GO:0008083DomainTransforming growth factor-beta, N-terminalMolecular Functiongrowth factor activity
BMP8A_HUMANIPR001111GO:0040007DomainTransforming growth factor-beta, N-terminalBiological Processgrowth
BMP8A_HUMANIPR001839GO:0008083DomainTransforming growth factor-beta, C-terminalMolecular Functiongrowth factor activity
BMP8A_HUMANIPR002405GO:0005576FamilyInhibin, alpha subunitCellular Componentextracellular region
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04340KEGG PATHWAYHedgehog signaling pathway
hsa04350KEGG PATHWAY@@TGF-beta signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q7Z5Y6_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q7Z5Y6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q7Z5Y6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB