AQP10:Aquaporin-10

Gene Name
Aquaporin-10
Protein ID
Q96PS8
Chromosome ID
1
HPP Status
2
Protein Name
Aquaporin-10
Synonyms

AQP-10

Aquaglyceroporin-10

aquaporin 10

aquaporin-10

AQPA_HUMAN

Small intestine aquaporin

small intestine aquaporin

aquaglyceroporin-10


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP10 ]
Chromosomal Position
1q21.3 | Start:154321090 End:154321090
Sequence
Q96PS8.fasta
Description

Entrez Gene Summary for AQP10
This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. (provided by RefSeq, Jul 2008)

UniProtKB Summary for AQP10
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP10 ]
External IDs
Hgnc ID: 16029 EntrezGene ID: 89872 Ensembl ID: ENSG00000143595
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP10 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12084581Results suggest that AQP10 represents a new member of aquaglyceroporins functionally as well as structurally.2010-01-21
15898950AQP10 with an insertion of 475 nt was localized in the capillary endothelium in villi of the small intestine and the isoform without the insertion localized in the gastro-entero-pancrestic endocrine cells.2010-01-21
17975119Observational study of gene-disease association. (HuGE Navigator)2008-12-03
18678926differential polarity and selective targeting of AQP3 and AQP10 in the intestinal epithelial cells is influenced by amino acid signal motifs.2010-01-21
19023099Observational study of gene-disease association. (HuGE Navigator)2009-03-25
19204726Observational study of gene-disease association. (HuGE Navigator)2009-03-25
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
21691092study unveiled the uniquely dual functional characteristic of hAQP10 as a carrier/channel for solute transport, providing a novel insight into its operation mechanism, which would help further elucidate its physiological role2011-10-22
21733844the presence of at least one glycosylated protein within each tetramer is sufficient to convey an enhanced structural stability to the remaining hAQP10 protomers of the tetramer.2011-12-10
23382902Aquaporin-10 is expressed exclusively in the adipocytes, which is particularly important for the maintenance of normal or low glycerol contents inside the adipocyte, thus protecting humans from obesity.2013-08-03
26313002the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells.2016-05-14
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
AQP10_HUMANIPR000425GO:0005215FamilyMajor intrinsic proteinMolecular Functiontransporter activity
AQP10_HUMANIPR000425GO:0006810FamilyMajor intrinsic proteinBiological Processtransport
AQP10_HUMANIPR000425GO:0016020FamilyMajor intrinsic proteinCellular Componentmembrane
AQP10_HUMANIPR026252GO:0006833FamilyAquaporin 10Biological Processwater transport
AQP10_HUMANIPR026252GO:0016021FamilyAquaporin 10Cellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-6 of 6 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
GVPAGLEPVVVGMLILALGLSMGANCGIPLNPARred-15.081ENSP00000318355Proteotypic
GVPAGLEPVVVGMLILALGLSMGANCGIPLNPARred-15.081ENSP00000318355Proteotypic
VFTQAPAEIMGHLRIRred-8.061ENSP00000318355Proteotypic
VFTQAPAEIMGHLRIRred-8.061ENSP00000318355Proteotypic
GVPAGLEPVVVGMLILALGLSMGANCGIPLNPARred-6.781ENSP00000318355Proteotypic
GVPAGLEPVVVGMLILALGLSMGANCGIPLNPARred-6.781ENSP00000318355Proteotypic
Evidence File
/mnt/mpp/ms_data/Q96PS8_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q96PS8_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q96PS8_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB