RGS13:Regulator of G-protein signaling 13

Gene Name
Regulator of G-protein signaling 13
Protein ID
Chromosome ID
HPP Status
Protein Name
Regulator of G-protein signaling 13

regulator of G-protein signaling 13

regulator of G-protein signalling 13

regulator of G-protein signalling 13

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS13 ]
Chromosomal Position
1q31.2 | Start:192636138 End:192636138

Entrez Gene Summary for RGS13
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. (provided by RefSeq, Jul 2008)

UniProtKB Summary for RGS13
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS13 ]
External IDs
Hgnc ID: 9995 EntrezGene ID: 6003 Ensembl ID: ENSG00000127074
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS13 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
11875076Functional characterization of the G protein regulator RGS132010-01-21
12970790Down-Regulation of regulator of G-protein signalling 13 is associated with mantle cell lymphoma2010-01-21
16565322RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.2010-01-21
19017978RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis.2010-01-21
20468064Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20627871Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20974683RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI.2011-03-19
21531726p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells2011-09-03


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

Showing 1-1 of 1 item.


Peptide SequenceSearch EngineBest ScoreBest Evidence IDBest Raw File IDBest Msms ScanAnnotation
Evidence File
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive

Showing 1-1 of 1 item.

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB