MLNR:Motilin receptor

Gene Name
Motilin receptor
Protein ID
Chromosome ID
HPP Status
Protein Name
Motilin receptor



G-protein coupled receptor 38


G protein-coupled receptor 38

G protein-coupled receptor 38

motilin receptor

[Reference: ]
Chromosomal Position
13q14.2 | Start:49220338 End:49220338

Entrez Gene Summary for MLNR
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. (provided by RefSeq, Aug 2011)

UniProtKB Summary for MLNR
Function: Receptor for motilin

Tocris Summary for MLNR
Motilin Receptors are Gq/11-protein-coupled receptors that mediate progastrokinetic effects. They are found at their highest concentrations in the nerves of the antral wall of the stomach and are also found at significant levels throughout the smooth muscle of the upper gastrointestinal (GI) tract and in the enteric nervous system. Motilin receptors promote gastric emptying after food intake and increase smooth muscle contraction in the GI tract. Motilin receptors have not been identified in rodents, but have been cloned in rabbits and humans. The human motilin receptor gene is localized on chromosome 13q14-q21.

[Reference: ]
External IDs
Hgnc ID: 4495 EntrezGene ID: 2862 Ensembl ID: ENSG00000102539
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
12054506The motilin pharmacophore in CHO cells expressing the human motilin receptor2010-01-21
16531413motilin receptor extracellular domains have roles in peptide and non-peptidyl agonist binding and activity2010-01-21
18032475action by different chemical classes of agonists that are known to interact with distinct regions of the motilin receptor likely yield a common activation state of the cytosolic face of this receptor2010-01-21
18183601The motilin receptor is expressed in human colonic and ileal smooth muscle. Further, motilin receptor expression was also shown in the mucosa.2010-01-21
18420306Desensitization and internalization of MLNR is independent of the C-terminal tail.2010-01-21
20424473Observational study of gene-disease association. (HuGE Navigator)2010-06-30
22465164The data suggested that in species expressing both motilin-MR and ghrelin-GHSR, there is a compensatory relationship in vivo.2013-02-09
23142315data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands2013-06-15


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
MTLR_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
MTLR_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
MTLR_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
MTLR_HUMANIPR003905GO:0007186FamilyGrowth hormone secretagogue receptor type 1Biological ProcessG-protein coupled receptor signaling pathway
MTLR_HUMANIPR003905GO:0016021FamilyGrowth hormone secretagogue receptor type 1Cellular Componentintegral to membrane
MTLR_HUMANIPR003905GO:0016520FamilyGrowth hormone secretagogue receptor type 1Molecular Functiongrowth hormone-releasing hormone receptor activity
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB