OR2M7:Olfactory receptor 2M7

Gene Name
Olfactory receptor 2M7
Protein ID
Q8NG81
Chromosome ID
1
HPP Status
2
Protein Name
Olfactory receptor 2M7
Synonyms

Olfactory receptor OR1-58

OR1-58

olfactory receptor, family 2, subfamily M, member 7

olfactory receptor OR1-58

olfactory receptor 2M7


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2M7 ]
Chromosomal Position
1q44 | Start:248323630 End:248323630
Sequence
Q8NG81.fasta
Description

Entrez Gene Summary for OR2M7
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul 2008)

UniProtKB Summary for OR2M7
Function: Odorant receptor (Potential)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2M7 ]
External IDs
Hgnc ID: 19594 EntrezGene ID: 391196 Ensembl ID: ENSG00000177186
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2M7 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20585627Observational study of gene-disease association. (HuGE Navigator)2010-09-15
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
OR2M7_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
OR2M7_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
OR2M7_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
OR2M7_HUMANIPR000725GO:0004984FamilyOlfactory receptorMolecular Functionolfactory receptor activity
OR2M7_HUMANIPR000725GO:0007186FamilyOlfactory receptorBiological ProcessG-protein coupled receptor signaling pathway
OR2M7_HUMANIPR000725GO:0016021FamilyOlfactory receptorCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04740KEGG PATHWAYOlfactory transduction
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q8NG81_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8NG81_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8NG81_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB

Other Evidence


Evidence Type

Deorphanization (Added by AJ, MQU Bioinformatics group)

Evidence Info

(S)-(-)-citronellol, Geraniol (Saito et al., 2009)

Reference
Odor coding by a mammalian receptor repertoire; Harumi Saito, Qiuyi Chi, Hanyi Zhuang, Hiroaki Matsunami, Joel Mainland, 2009, 'Odor coding by a mammalian receptor repertoire', Neuroscience Research, vol. 65, p. S76
Contributed By
MQU Bioinformatics