TAS1R2:Taste receptor type 1 member 2

Gene Name
Taste receptor type 1 member 2
Protein ID
Q8TE23
Chromosome ID
1
HPP Status
3
Protein Name
Taste receptor type 1 member 2
Synonyms

G protein-coupled receptor 71

TR2

sweet taste receptor T1R2

taste receptor type 1 member 2

taste receptor, type 1, member 2

Sweet taste receptor T1R2

T1R2

G-protein coupled receptor 71

GPR71


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R2 ]
Chromosomal Position
1p36.13 | Start:18839599 End:18839599
Sequence
Q8TE23.fasta
Description

UniProtKB Summary for TAS1R2
Function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R2 ]
External IDs
Hgnc ID: 14905 EntrezGene ID: 80834 Ensembl ID: ENSG00000179002
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12706725The mechanism of interaction of the sweet protein monellin with the T1R2-T1R3 receptor.2010-01-21
14636554sweet and umami taste are strictly dependent on T1R-receptors, and show that selective elimination of T1R-subunits differentially abolishes detection and perception of these two taste modalities2010-01-21
16633339water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water2010-01-21
17935609Some of the amino acid positions crucial for activation of hTAS1R2+hTAS1R3 by neohesperidin dihydrochalcone are involved in the binding of allosteric modulators in other class C GPCRs2010-01-21
19664591Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy.2010-04-12
20173092Data show that Positive allosteric modulators of the sweet taste receptor could help reduce the caloric content in food and beverages while maintaining the desired taste.2010-05-31
20302879Results from mutagenesis and chimeras of the receptor indicated that brazzein interacts with both T1R2 and T1R3 and that the Venus flytrap module of T1R2 is important for brazzein agonism.2010-05-10
20468064Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20858777Observational study of gene-disease association. (HuGE Navigator)2010-12-05
20858777significant associations were seen in TAS1R2 for caries risk and/or protection.2010-10-30
20943793Observational study of gene-disease association. (HuGE Navigator)2010-12-05
20943793Our findings show that a genetic variation in TAS1R2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling.2011-01-01
21540445T1R2/T1R3 is involved in glucose-dependent secretion of satiation peptides2011-10-01
22315413Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo.2012-04-14
23257979associated with caries risk2013-10-19
23349025Interaction between brazzein and the amino terminal domain of the sweet receptor subunit T1R2 showed a stronger interaction at 7 degrees C than at 37 degrees C.; the low temperature conformation, alters the orientations of 2 loops known to be critical for the sweetness of brazzein, may represent the bound state of brazzei in the complex with the human sweet receptor.2013-12-14
24068707effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R32014-01-25
25029362human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r32015-03-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
TS1R2_HUMANIPR000337GO:0004930FamilyGPCR, family 3Molecular FunctionG-protein coupled receptor activity
TS1R2_HUMANIPR000337GO:0007186FamilyGPCR, family 3Biological ProcessG-protein coupled receptor signaling pathway
TS1R2_HUMANIPR000337GO:0016021FamilyGPCR, family 3Cellular Componentintegral to membrane
TS1R2_HUMANIPR011500GO:0004930DomainGPCR, family 3, nine cysteines domainMolecular FunctionG-protein coupled receptor activity
TS1R2_HUMANIPR011500GO:0007186DomainGPCR, family 3, nine cysteines domainBiological ProcessG-protein coupled receptor signaling pathway
TS1R2_HUMANIPR017978GO:0004930DomainGPCR, family 3, C-terminalMolecular FunctionG-protein coupled receptor activity
TS1R2_HUMANIPR017978GO:0007186DomainGPCR, family 3, C-terminalBiological ProcessG-protein coupled receptor signaling pathway
TS1R2_HUMANIPR017978GO:0016021DomainGPCR, family 3, C-terminalCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04742KEGG PATHWAYTaste transduction
hsa04973KEGG PATHWAYCarbohydrate digestion and absorption
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q8TE23_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8TE23_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8TE23_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB