RGS21:Regulator of G-protein signaling 21

Gene Name
Regulator of G-protein signaling 21
Protein ID
Q2M5E4
Chromosome ID
1
HPP Status
2
Protein Name
Regulator of G-protein signaling 21
Synonyms

regulator of G-protein signalling 21

regulator of G-protein signaling 21

regulator of G-protein signalling 21


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS21 ]
Chromosomal Position
1q31.2 | Start:192316992 End:192316992
Sequence
Q2M5E4.fasta
Description

Entrez Gene Summary for RGS21
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.(supplied by OMIM, Nov 2008)

UniProtKB Summary for RGS21
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS21 ]
External IDs
Hgnc ID: 26839 EntrezGene ID: 431704 Ensembl ID: ENSG00000253148
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RGS21 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
16302027RGS21 mRNA is expressed ubiquitously in the 16 tissues examined, implying general physiological roles.2010-01-21
23095746RGS21 modulates bitter taste signal transduction.2013-02-16
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceRGS21_HUMANRGS4_RAT15213051.5485.536309138501792.00E-35143
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RGS21_HUMANIPR000342GO:0038032DomainRegulator of G protein signallingBiological Processtermination of G-protein coupled receptor signaling pathway
RGS21_HUMANIPR016137GO:0038032DomainRegulator of G protein signalling superfamilyBiological Processtermination of G-protein coupled receptor signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q2M5E4_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q2M5E4_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB