QRFP:Orexigenic neuropeptide QRFP

Gene Name
Orexigenic neuropeptide QRFP
Protein ID
Chromosome ID
HPP Status
Protein Name
Orexigenic neuropeptide QRFP

P518 precursor protein

RF(Arg-Phe)amide family 26 amino acid peptide (P518)




pyroglutamylated RFamide peptide



orexigenic neuropeptide QRFP

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
Chromosomal Position
9q34.12 | Start:130892702 End:130892702

Entrez Gene Summary for QRFP
The P518 precursor protein can be processed into several RF (arg-phe)-amide peptides, including P518. RF-amide peptides share a common C-terminal motif and are involved in cell signaling through G protein-coupled receptors (Jiang et al., 2003 (PubMed 12714592)).(supplied by OMIM, Mar 2008)

UniProtKB Summary for QRFP
Function: Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
External IDs
Hgnc ID: 29982 EntrezGene ID: 347148 Ensembl ID: ENSG00000188710
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=QRFP ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
12714592P518 exhibited high affinity for SP9155. The peptide P518 precursor gene is predominantly expressed in various brain regions, coronary arteries, thyroid and parathyroid glands, large intestine, colon, bladder, testes, and prostate.2010-01-21
15808908Solution conformation of 26RFa by using two-dimensional NMR spectroscopy in different media was investigated.2010-01-21
15891009A bioinformatic search for peptides related to frog 26RFa reveals the presence of homologous sequences in the human genome.2010-01-21
16899066Characterization of 26RFa-related peptides showed that two distinct molecular forms of 26RFa are present in the human hypothalamus and spinal cord, i.e. 26RFa and an N-terminally elongated form of 43 amino acids designated 43RFa.2010-01-21
20534693Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.2010-11-27
22466335High levels of circulating 26RFa observed in anorexia nervosa patients might reflect an adaptive mechanism of the organism to promote energy intake and to increase fat stores in response to undernutrition.2012-08-18
22863147Data indicate that 26RFa may participate to the development of prostate cancer at the androgen independent state by promoting the neuroendocrine differentiation and the migration of cancer cells via autocrine/paracrine mechanisms.2013-05-11
25858563we show a moderate positive correlation between plasma 26RFa levels and insulin in patients with diabetes. Plasma 26RFa increases in response to glucose tolerance test. 26RFa and its receptor GPR103 are present in human pancreatic beta-cells and gut.2015-10-10


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceOX26_HUMANOX26_RAT13611962.1887.535317135161244E-32132
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
OX26_HUMANIPR024565GO:0031854FamilyOrexigenic neuropeptide QRFP/P518Molecular Functionorexigenic neuropeptide QRFP receptor binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive