LCE2B:Late cornified envelope protein 2B

Gene Name
Late cornified envelope protein 2B
Protein ID
O14633
Chromosome ID
1
HPP Status
2
Protein Name
Late cornified envelope protein 2B
Synonyms

Skin-specific protein Xp5

Small proline-rich-like epidermal differentiation complex protein 1B

late envelope protein 10

small proline rich-like (epidermal differentiation complex) 1B

Late envelope protein 10

XP5

skin-specific protein Xp5

small proline-rich-like epidermal differentiation complex protein 1B

late cornified envelope 2B

LEP10

late cornified envelope protein 2B

SPRL1B


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LCE2B ]
Chromosomal Position
1q21.3 | Start:152686123 End:152686123
Sequence
O14633.fasta
Description

Entrez Gene Summary for LCE2B
This gene is one of the at least 20 genes expressed during epidermal differentiation and located on chromosomal band 1q21. This gene is involved in epidermal differentiation, and it is expressed at high levels in normal and psoriatic skin, but not in cultured keratinocytes or in any other tested cell types or tissues. (provided by RefSeq, Jul 2008)

UniProtKB Summary for LCE2B
Function: Precursors of the cornified envelope of the stratum corneum

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LCE2B ]
External IDs
Hgnc ID: 16610 EntrezGene ID: 26239 Ensembl ID: ENSG00000159455
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LCE2B ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11698679XP5 is part of a cluster of genes (LEP genes) whose proteins incorporate into keratinocyte cornified envelopes. Strong skin expression confirmed.2001-11-18
15854049paper describing nomenclature changes and expression in range of tissues and in response to UV2005-07-12
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
LCE2B_HUMANIPR028205GO:0008544FamilyLate cornified envelope proteinBiological Processepidermis development
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O14633_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O14633_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O14633_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB