TAS1R1:Taste receptor type 1 member 1

Gene Name
Taste receptor type 1 member 1
Protein ID
Q7RTX1
Chromosome ID
1
HPP Status
2
Protein Name
Taste receptor type 1 member 1
Synonyms

taste receptor, type 1, member 1

GPR70

TR1

G-protein coupled receptor 70

G protein-coupled receptor 70

taste receptor type 1 member 1

seven transmembrane helix receptor

T1R1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R1 ]
Chromosomal Position
1p36.31 | Start:6555181 End:6555181
Sequence
Q7RTX1.fasta
Description

Entrez Gene Summary for TAS1R1
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB Summary for TAS1R1
Function: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R1 ]
External IDs
Hgnc ID: 14448 EntrezGene ID: 80835 Ensembl ID: ENSG00000173662
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TAS1R1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11894099sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses2010-01-21
15353592findings demonstrate the different functional roles of T1R3 and T1R2 and the presence of multiple ligand binding sites on the sweet taste receptor2010-01-21
17506496In vivo taste bud signaling may proceed primarily through hT1R1 and hT1R2.2010-01-21
17724330human duodenal L cells express sweet taste receptor T1r.2010-01-21
19146926Taken together, these results suggest that Tas1R1-Tas1R3 receptor variants found in human fungiform papillae might contribute to inter-individual differences of sensitivity to L-glutamate.2010-01-21
19571223In our sample of subjects, the frequencies of 2 nsSNPs, C329T in tas1r1 and C2269T in tas1r3, were significantly higher in [glutamate] nontasters than expected, whereas G1114A in tas1r1 was more frequent in tasters.2010-01-21
19587085Observational study of gene-disease association. (HuGE Navigator)2009-08-12
20468064Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20660057Observational study of gene-disease association. (HuGE Navigator)2010-09-15
21422378amino acid substitutions (A110V and R507Q) in the N-terminal ligand-binding domain of T1R1 severely impair receptor functions in vitro2011-12-24
22427794Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa.2012-06-23
24000232The study provides human psychophysical evidence that TAS1R1 polymorphisms associate with modest differences in overall taste intensity, which were independent from other well-studied markers of variation in oral sensation.2014-04-05
24214976A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3.2014-02-22
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
TS1R1_HUMANIPR000337GO:0004930FamilyGPCR, family 3Molecular FunctionG-protein coupled receptor activity
TS1R1_HUMANIPR000337GO:0007186FamilyGPCR, family 3Biological ProcessG-protein coupled receptor signaling pathway
TS1R1_HUMANIPR000337GO:0016021FamilyGPCR, family 3Cellular Componentintegral to membrane
TS1R1_HUMANIPR011500GO:0004930DomainGPCR, family 3, nine cysteines domainMolecular FunctionG-protein coupled receptor activity
TS1R1_HUMANIPR011500GO:0007186DomainGPCR, family 3, nine cysteines domainBiological ProcessG-protein coupled receptor signaling pathway
TS1R1_HUMANIPR017978GO:0004930DomainGPCR, family 3, C-terminalMolecular FunctionG-protein coupled receptor activity
TS1R1_HUMANIPR017978GO:0007186DomainGPCR, family 3, C-terminalBiological ProcessG-protein coupled receptor signaling pathway
TS1R1_HUMANIPR017978GO:0016021DomainGPCR, family 3, C-terminalCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04742KEGG PATHWAYTaste transduction
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q7RTX1_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q7RTX1_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q7RTX1_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB