YY2:Transcription factor YY2

Gene Name
Transcription factor YY2
Protein ID
O15391
Chromosome ID
X
HPP Status
2
Protein Name
Transcription factor YY2
Synonyms

"transcription factor yin yang 2"

yin and yang 2

transcription factor YY2

Zinc finger protein 631

YY2 transcription factor

ZNF631

YY-2

Yin and yang 2

zinc finger protein 631

transcription factor yin yang 2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=YY2 ]
Chromosomal Position
Xp22.12 | Start:21855987 End:21855987
Sequence
O15391.fasta
Description

Entrez Gene Summary for YY2
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. (provided by RefSeq, May 2010)

UniProtKB Summary for YY2
Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=YY2 ]
External IDs
Hgnc ID: 31684 EntrezGene ID: 404281 Ensembl ID: ENSG00000230797
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=YY2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15087442YY2 can bind to and regulate some promoters known to be controlled by YY1. Similar to YY1, YY2 contains both transcriptional activation and repression functions.2010-01-21
16260628the novel factor YY2 antagonizes the negative actions exerted by YY12010-01-21
19026728yy2 expression is mediated by its own methylation-sensitive promoter.2010-01-21
20215434Results show that human YY2 is not redundant to YY1, and YY2 is a significant regulator of genes previously identified as uniquely responding to YY1.2010-08-02
22248057article summarizes all critical aspects that are (or will be) relevant for a better understanding of YY1- and/or YY2-mediated cellular control mechanisms2012-03-24
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceTYY2_HUMANTYY1_MOUSE37241650.72111.831579137114136E-95343
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
TYY2_HUMANIPR013087GO:0003676DomainZinc finger C2H2-type/integrase DNA-binding domainMolecular Functionnucleic acid binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




MaxQB

Evidence File
/mnt/mpp/ms_data/O15391_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O15391_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
SATSTEANPAGSSSSLGTRMaxquant170.61012229888513010
Evidence File
/mnt/mpp/ms_data/O15391_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB