ADRA1D:Alpha-1D adrenergic receptor

Gene Name
Alpha-1D adrenergic receptor
Protein ID
P25100
Chromosome ID
20
HPP Status
1
Protein Name
Alpha-1D adrenergic receptor
Synonyms

alpha-1D adrenergic receptor

dJ779E11.2

adrenergic, alpha-1A-, receptor

ADRA1A

alpha-adrenergic receptor 1a

alpha-1A adrenergic receptor

alpha-1D-adrenergic receptor

Alpha-1D adrenoreceptor

ADRA1R

alpha-1D adrenoceptor

Alpha-adrenergic receptor 1a

ALPHA1

adrenoceptor alpha 1D

adrenergic, alpha -1D-, receptor

DAR

Alpha-1A adrenergic receptor

ADRA1

alpha-1D adrenoreceptor

Alpha-1D adrenoceptor

adrenergic, alpha-1D-, receptor


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA1D ]
Chromosomal Position
20p13 | Start:4220631 End:4220631
Sequence
P25100.fasta
Description

Entrez Gene Summary for ADRA1D
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ADRA1D
Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium

Tocris Summary for ADRA1D
Adrenergic alpha1 receptors (alpha1-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha2A, alpha2B, alpha2C, beta1, beta2 and beta3. The adrenergic alpha1 receptors are further divided into three subtypes: alpha1A, alpha1B and alpha1D receptors. lpha1-adrenoceptors are widely distributed in both the CNS and periphery where they play a major role in smooth muscle contraction. A fourth alpha1 receptor subtype has been postulated and is designated as alpha1L based on its low affinity for prazosin. It has been suggested that this subtype may represent a different conformational state of the alpha1A subtype.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA1D ]
External IDs
Hgnc ID: 280 EntrezGene ID: 146 Ensembl ID: ENSG00000171873
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA1D ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12409310Data show thah activation of alpha(1)A- or alpha(1)B-adrenergic receptors inhibits serum-promoted cell proliferation, whereas alpha(1)D-AR activation does not show such an inhibitory effect.2010-01-21
12442007Observational study of gene-disease association. (HuGE Navigator)2008-03-13
14626446These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail.2010-01-21
14736874cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors2010-01-21
15297446alpha(1A)- and alpha(1D)-adrenergic receptors mediate G(1)-S cell-cycle arrest2010-01-21
15690361Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs.2010-01-21
16533813alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction2010-01-21
17384146Differential methylation of proximal GC boxes in the ADRA1D promoter disrupts Sp1 binding in a cell-specific manner resulting in repression of basal alpha1dAR expression.2010-01-21
17404580ADRA1D polymorphisms are predictive markers of the response to beta-blockers2010-01-21
17404580Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-03-13
17660397Stimulation of alpha(1D)-ARs by picomolar phenylephrine concentrations devoid of any contractile vascular effects, induces a proangiogenic phenotype in endothelial cells that is enhanced in a hypoxic environment.2010-01-21
17681068In the proximal and medial ureter, the distribution of ARs was alpha 1d > or = alpha 1a > alpha 1b; In the distal ureter, the distribution of ARs was alpha 1d > alpha 1a > alpha 1b2010-01-21
17973108expression in distal ureter higher than in proximal and mid ureter but not statistically significant2010-01-21
18187928Investigate role of ADRA1D amino residues in binding of beta-adrenergic antagonists (prazosin/tamulosin).2010-01-21
18257748ADRA1A expression was decreased in end stage renal disease. Functional receptor changes mediated vascular hypersensitivity to phenylephrine.2010-01-21
18628404ADRA1D induces vascular smooth muscle apoptosis via a p53-dependent mechanism.2010-01-21
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19458937Our data indicate that carboxyl terminus-truncated alpha(1D)-adrenoceptors are fully functional and subjected to regulation by phosphorylation. The roles of the carboxyl termini differ among alpha(1)-adrenoceptor subtypes.2010-01-21
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
21063774Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene.2011-01-22
21063774Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-12-05
21115837Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome.2011-05-14
23205498alpha(1)(D)-adrenoceptors in the lower urinary tract might play an important role in the pathophysiology of lower urinary tract disorders. [review]2013-07-06
23877383Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively.2014-06-07
24844469alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts.2015-09-05
25481381Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.2015-07-25
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceADA1D_HUMANADA1B_MESAU57231666.4655.24103195410443566E-109390
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ADA1D_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
ADA1D_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
ADA1D_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
ADA1D_HUMANIPR000363GO:0004937FamilyAlpha 1D adrenoceptorMolecular Functionalpha1-adrenergic receptor activity
ADA1D_HUMANIPR000363GO:0007186FamilyAlpha 1D adrenoceptorBiological ProcessG-protein coupled receptor signaling pathway
ADA1D_HUMANIPR000363GO:0016021FamilyAlpha 1D adrenoceptorCellular Componentintegral to membrane
ADA1D_HUMANIPR002233GO:0004935FamilyAdrenoceptor familyMolecular Functionadrenergic receptor activity
ADA1D_HUMANIPR002233GO:0007186FamilyAdrenoceptor familyBiological ProcessG-protein coupled receptor signaling pathway
ADA1D_HUMANIPR002233GO:0016021FamilyAdrenoceptor familyCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04020KEGG PATHWAYCalcium signaling pathway
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
hsa04270KEGG PATHWAYVascular smooth muscle contraction
hsa04970KEGG PATHWAYSalivary secretion
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P25100_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/P25100_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P25100_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB