FOXD4:Forkhead box protein D4

Gene Name
Forkhead box protein D4
Protein ID
Q12950
Chromosome ID
9
HPP Status
2
Protein Name
Forkhead box protein D4
Synonyms

FOXD4A

Myeloid factor-alpha

myeloid factor-alpha

forkhead, Drosophila, homolog-like 9

forkhead-related activator 5

forkhead box protein D4

FKHL9

forkhead box D4

forkhead-related transcription factor 5

FREAC5

FREAC-5

forkhead-related protein FKHL9

Forkhead-related protein FKHL9

Forkhead-related transcription factor 5


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXD4 ]
Chromosomal Position
9p24.3 | Start:116231 End:116231
Sequence
Q12950.fasta
Description

Entrez Gene Summary for FOXD4
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. (provided by RefSeq, Mar 2012)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXD4 ]
External IDs
Hgnc ID: 3805 EntrezGene ID: 2298 Ensembl ID: ENSG00000170122
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FOXD4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
17273782The W148R mutation disrupts an extremely highly conserved tryptophan residue in the forkhead domain of FOXD4, possibly resulting in reduced DNA binding capacity and altered transcriptional activity.2010-01-21
22876580FOXd4 encodes forkhead box D4 protein.2012-09-01
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceFOXD4_HUMANFOXD3_RAT4398988.7620.271001041923915E-43171
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
FOXD4_HUMANIPR001766GO:0003700DomainTranscription factor, fork headMolecular Functionsequence-specific DNA binding transcription factor activity
FOXD4_HUMANIPR001766GO:0043565DomainTranscription factor, fork headMolecular Functionsequence-specific DNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q12950_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q12950_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q12950_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB